A new standard of care for patients with surgically unresectable stage III non-small cell lung cancer

被引:1
|
作者
Gill, Harpaul S. [1 ]
Ramalingam, Suresh S. [1 ]
机构
[1] Emory Univ, Sch Med, Dept Hematol & Oncol, Winship Canc Inst, 1365 Clifton Rd NE,Bldg C,Suite 4014, Atlanta, GA 30322 USA
关键词
durvalumab; immune checkpoint inhibition; NSCLC; PACIFIC trial; stage III NSCLC; RANDOMIZED PHASE-III; RADIATION-THERAPY; CONCURRENT CHEMORADIOTHERAPY; SEQUENTIAL CHEMORADIOTHERAPY; CONSOLIDATION DOCETAXEL; THORACIC RADIOTHERAPY; TRIAL; CHEMOTHERAPY; COMBINATION; CARBOPLATIN;
D O I
10.1002/cncr.31996
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Overall survival data from the PACIFIC trial have reaffirmed earlier US Food and Drug Administration approval of durvalumab in patients with stage III non-small cell lung cancer. In the current commentary, the authors provide a brief historical perspective on stage III disease as well as a further analysis of the strengths and weaknesses of the trial.
引用
收藏
页码:2148 / 2153
页数:6
相关论文
共 50 条
  • [31] Consolidation osimertinib for unresectable stage III epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer: redefining standard care
    Wu, Fang
    Zeng, Yue
    Neal, Joel W.
    TRANSLATIONAL LUNG CANCER RESEARCH, 2024, 13 (10) : 2853 - 2855
  • [32] Phase I study of concurrent chemoradiation with pemetrexed and cisplatin followed by consolidation pemetrexed for patients with unresectable stage III non-small cell lung cancer
    Cardenal, Felipe
    Arnaiz, Maria Dolores
    Moran, Teresa
    Jove, Josep
    Nadal, Ernest
    Porta, Ruth
    Sole, Josep Maria
    Brao, Isabel
    Palmero, Ramon
    Fuentes, Rafael
    Nunez, Inmaculada
    Caveda, Elena
    Cassinello, Alejo
    LUNG CANCER, 2011, 74 (01) : 69 - 74
  • [33] Maintenance and Consolidation Therapy in Patients with Unresectable Stage III/IV Non-Small Cell Lung Cancer
    Thatcher, Nicholas
    Heighway, Jim
    ONCOLOGIST, 2010, 15 (10): : 1034 - 1042
  • [34] Consolidation treatment of durvalumab after chemoradiation in real-world patients with stage III unresectable non-small cell lung cancer
    Chu Chia-Hsun
    Chiu Tzu-Hsuan
    Wang Chin-Chou
    Chang Wen-Chen
    Huang Allen Chung-Cheng
    Liu Chien-Ying
    Wang Chih-Liang
    Ko Ho-Wen
    Chung Fu-Tsai
    Hsu Ping-Chih
    Guo Yi-Ke
    Kuo, Chih-Hsi S.
    Yang Cheng-Ta
    THORACIC CANCER, 2020, 11 (06) : 1541 - 1549
  • [35] Concurrent gemcitabine and 3D radiotherapy in patients with stage III unresectable non-small cell lung cancer
    Gerald SMA Kerner
    Leon FA van Dullemen
    Erwin M Wiegman
    Joachim Widder
    Edwin Blokzijl
    Ellen M Driever
    John WG van Putten
    Jeroen JW Liesker
    Tineke EJ Renkema
    Remge M Pieterman
    Marc JF Mertens
    Thijo JN Hiltermann
    Harry JM Groen
    Radiation Oncology, 9
  • [36] Real-World Insights into the Impact of Durvalumab on Stage III Unresectable Non-Small Cell Lung Cancer-A Narrative Review
    Facheris, Giorgio
    Cossali, Gianluca
    Imbrescia, Jessica
    La Mattina, Salvatore
    Mataj, Eneida
    Meli, Nicole
    Volpi, Giulia
    Triggiani, Luca
    Guerini, Andrea Emanuele
    Levi, Guido
    Grisanti, Salvatore
    di Monale e Bastia, Michela Buglione
    Borghetti, Paolo
    CANCERS, 2025, 17 (05)
  • [37] Comparison of chemotherapy regimens for concurrent chemoradiotherapy in unresectable stage III non-small cell lung cancer
    Harada, Hideyuki
    Yamamoto, Nobuyuki
    Takahashi, Toshiaki
    Endo, Masahiro
    Murakami, Haruyasu
    Tsuya, Asuka
    Nakamura, Yukiko
    Ono, Akira
    Igawa, Satoshi
    Shukuya, Takehito
    Tamiya, Akihiro
    Nishimura, Tetsuo
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2009, 14 (06) : 507 - 512
  • [38] Single-center comparison of multiple chemotherapy regimens for concurrent chemoradiotherapy in unresectable stage III non-small-cell lung cancer
    Tabchi, Samer
    Blais, Normand
    Campeau, Marie-Pierre
    Tehfe, Mustapha
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2017, 79 (02) : 381 - 387
  • [39] Chemoradiation for stage III non-small cell lung cancer
    Ramella, Sara
    Fiore, Michele
    Iurato, Aurelia
    Trodella, Luca E.
    Trodella, Lucio
    D'Angelillo, Rolando M.
    EUROPEAN JOURNAL OF ONCOLOGY, 2013, 18 (01): : 5 - 13
  • [40] Immunotherapy for Unresectable Stage III Non-Small-Cell Lung Cancer
    Rizvi, Naiyer A.
    Peters, Solange
    NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (20): : 1986 - 1988