Paraoxonase 1 and atherosclerosis-related diseases

被引：61

作者：

Kotur-Stevuljevic, Jelena ^{[1
]}

Vekic, Jelena ^{[1
]}

Stefanovic, Aleksandra ^{[1
]}

Zeljkovic, Aleksandra ^{[1
]}

Ninic, Ana ^{[1
]}

Ivanisevic, Jasmina ^{[1
]}

Miljkovic, Milica ^{[1
]}

Sopic, Miron ^{[1
]}

Munjas, Jelena ^{[1
]}

Mihajlovic, Marija ^{[1
]}

Spasic, Slavica ^{[1
]}

Jelic-Ivanovic, Zorana ^{[1
]}

Spasojevic-Kalimanovska, Vesna ^{[1
]}

机构：

[1] Univ Belgrade, Fac Pharm, Dept Med Biochem, POB 146, Belgrade 11000, Serbia

来源：

BIOFACTORS | 2020年 / 46卷 / 02期

关键词：

atherosclerosis; cancer; cardiovascular disease; diabetes; HDL dysfunction; paraoxonase; 1; renal disease; stroke; HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; APOLIPOPROTEIN-A-I; OBSTRUCTIVE PULMONARY-DISEASE; HDL PARTICLE-SIZE; OXIDATIVE STRESS; DIABETES-MELLITUS; PON1; ACTIVITY; HEART-DISEASE; CARDIOVASCULAR-DISEASE;

D O I：

10.1002/biof.1549

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features.

引用

页码：193 / 205

页数：13

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