A new route for the preparation of 5-hydroxyisophthalic acid

被引：8

作者：

Gelmont, M ^{[1
]}

Oren, J ^{[1
]}

机构：

[1] IMI TAMI Inst Res & Dev Ltd, IL-26111 Haifa, Israel

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2002年 / 6卷 / 05期

关键词：

D O I：

10.1021/op0100302

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new, simple and practical, two-stage process for the preparation of 5-hydroxyisophthalic acid (5-HIPA) from isophthalic acid is described. In the first stage, isophthalic acid is brominated by bromine in oleum, in the presence of an iodine catalyst, to give crude 5-bromoisophthalic acid (15-BIPA). In the second stage the crude 5-BIPA is hydrolyzed with aqueous NaOH, in the presence of a copper catalyst, to give crude 5-HIPA, with a purity of ca. 98%. Both stages of the process were optimized. A single crystallization of the crude 5-HIPA from water gives the product in a purity of more than 99%. The overall yield of pure 5-HIPA is 65-70%.

引用

页码：591 / 596

页数：6

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