A new route for the preparation of 5-hydroxyisophthalic acid

被引:8
作者
Gelmont, M [1 ]
Oren, J [1 ]
机构
[1] IMI TAMI Inst Res & Dev Ltd, IL-26111 Haifa, Israel
关键词
D O I
10.1021/op0100302
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A new, simple and practical, two-stage process for the preparation of 5-hydroxyisophthalic acid (5-HIPA) from isophthalic acid is described. In the first stage, isophthalic acid is brominated by bromine in oleum, in the presence of an iodine catalyst, to give crude 5-bromoisophthalic acid (15-BIPA). In the second stage the crude 5-BIPA is hydrolyzed with aqueous NaOH, in the presence of a copper catalyst, to give crude 5-HIPA, with a purity of ca. 98%. Both stages of the process were optimized. A single crystallization of the crude 5-HIPA from water gives the product in a purity of more than 99%. The overall yield of pure 5-HIPA is 65-70%.
引用
收藏
页码:591 / 596
页数:6
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