Callistrilones A and B, Triketone-Phloroglucinol-Monoterpene Hybrids with a New Skeleton from Callistemon rigidus

被引：73

作者：

Cao, Jia-Qing ^{[1
]}

Huang, Xiao-Jun ^{[1
,2
]}

Li, Yu-Ting ^{[1
]}

Wang, Ying ^{[1
,2
]}

Wang, Lei ^{[1
,2
]}

Jiang, Ren-Wang ^{[1
]}

Ye'tt, Wen-Cai ^{[1
,2
]}

机构：

[1] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, JNU HKUST Joint Lab Neurosci & Innovat Drug Res, Guangzhou 510632, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 01期

基金：

中国国家自然科学基金;

关键词：

3 UNUSUAL MEROTERPENOIDS; DIELS-ALDER ADDUCTS; LEAVES; ACYLPHLOROGLUCINOLS;

D O I：

10.1021/acs.orglett.5b03360

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first triketone-phloroglucinol-monoterpene hybrids, callistrilones A and B (1 and 2), along with a postulated biosynthetic intermediate (3) were isolated from the leaves of Callistemon rigidus. Compounds 1 and 2 featured a new carbon skeleton with an unprecedented [1]benzofuro-[2,3-a]xanthene or [1]benzofuro[3,2-b]xanthene pentacyclic ring system composed of three kinds of building blocks. Their structures and absolute configurations were elucidated by spectroscopic analysis, X-ray diffraction, and electronic circular dichroism (ECD) calculations. A plausible biogenetic pathway for the new compounds is also proposed. Compound 1 exhibited moderate antibacterial activity against Gram-positive bacteria including multiresistant strains.

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收藏

页码：120 / 123

页数：4

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