Oral medication via feed and water - pharmacological aspects

被引:10
作者
Kietzmann, Manfred [1 ]
Baeumer, Wolfgang [1 ]
机构
[1] Univ Vet Med Hannover, Inst Pharmakol Toxikol & Pharm, D-30559 Hannover, Germany
来源
DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT | 2009年 / 116卷 / 06期
关键词
oral medication; feed; water; bioavailability; PHARMACODYNAMICS; BREAKPOINTS; PARAMETERS; ANIMALS;
D O I
10.2376/0341-6593-116-204
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
By treatment of single animals or a live stock a treatment regimen has to be chosen, which guarantees a sufficient concentration of the administered drug in the target tissue. On the other hand, particular care has to be taken to avoid that single animals get a too high, intolerable dose of the administered drug. These elementary requirements must be met by the attending veterinarian. The treatment schedule must be in line with the current phamaceutical law. Some of the most outstanding problems associated with application via feed and water are discussed. Crucial factors apart from practicability are the bioavailability depending on pharmaceutical form and the avoidance of displacements of drugs. Future efforts should focus on the optimization of oral medication.
引用
收藏
页码:204 / 208
页数:5
相关论文
共 19 条
[1]   Antimicrobial pharmacodynamics [J].
Ambrose, PG ;
Owens, RC ;
Grasela, D .
MEDICAL CLINICS OF NORTH AMERICA, 2000, 84 (06) :1431-+
[2]  
BLEYL DWR, 2007, AMTSARZTL DIENST LEB, V14, P1
[3]   INTERRELATIONSHIP BETWEEN PHARMACOKINETICS AND PHARMACODYNAMICS IN DETERMINING DOSAGE REGIMENS FOR BROAD-SPECTRUM CEPHALOSPORINS [J].
CRAIG, WA .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1995, 22 (1-2) :89-96
[4]   Pharmacokinetic/pharmacodynamic parameters: Rationale for antibacterial dosing of mice and men [J].
Craig, WA .
CLINICAL INFECTIOUS DISEASES, 1998, 26 (01) :1-10
[5]   In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus [J].
Firsov, AA ;
Vostrov, SN ;
Lubenko, IY ;
Drlica, K ;
Portnoy, YA ;
Zinner, SH .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (05) :1604-1613
[6]   Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84) [J].
Haslam, I. S. ;
Jones, K. ;
Coleman, T. ;
Simmons, N. L. .
BIOCHEMICAL PHARMACOLOGY, 2008, 76 (07) :850-861
[7]   Optimisation of antimicrobial therapy using pharmacokinetic and pharmacodynamic parameters [J].
Jacobs, MR .
CLINICAL MICROBIOLOGY AND INFECTION, 2001, 7 (11) :589-596
[8]  
KAEMMERER K, 1981, KRAFTFUTTER, V64, P2
[9]  
Kamphues J, 1996, DEUT TIERARZTL WOCH, V103, P250
[10]  
Kietzmann M, 1995, DEUT TIERARZTL WOCH, V102, P441