Visible-Light-Promoted Redox Neutral C-H Amidation of Heteroarenes with Hydroxylamine Derivatives

被引：147
|
作者：
Qin, Qixue [1 ]
Yu, Shouyun [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 13期
基金：
中国国家自然科学基金;
关键词：
N BOND FORMATION; NITROGEN-CENTERED RADICALS; PHOTOREDOX CATALYSIS; ROOM-TEMPERATURE; AMIDYL RADICALS; PD(II)-CATALYZED AMINATION; SYNTHETIC APPLICATIONS; COUPLING REACTIONS; ORGANIC-SYNTHESIS; FUNCTIONALIZATION;
D O I：
10.1021/ol501457s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A room temperature redox neutral direct C H amidation of heteroarenes has been achieved. Hydroxylamine derivatives, which are easily accessed, have been employed as tunable nitrogen sources. These reactions were enabled by a visible-light-promoted single-electron transfer pathway without a directing group. A variety of heteroarenes, such as indoles, pyrroles, and furans, could go through this amidation with high yields (up to 98%). These reactions are highly regioselective, and all the products were isolated as a single regioisomer.
引用
收藏
页码：3504 / 3507
页数：4
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