Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice

被引：28

作者：

Wilson, George D. ^{[1
]}

Wilson, Thomas G. ^{[1
]}

Hanna, Alaa ^{[1
]}

Fontanesi, Giovanni ^{[1
]}

Kulchycki, Justin ^{[1
]}

Buelow, Katie ^{[1
]}

Pruetz, Barbara L. ^{[2
]}

Michael, Daniel B. ^{[3
,4
]}

Chinnaiyan, Prakash ^{[1
]}

Maddens, Michael E. ^{[5
]}

Martinez, Alvaro A. ^{[6
]}

Fontanesi, James ^{[1
,4
]}

机构：

[1] Beaumont Hlth, Radiat Oncol Dept, Royal Oak, MI USA

[2] Beaumont Hlth, Beaumont Biobank, Royal Oak, MI USA

[3] Michigan Head & Spine Inst, Southfield, MI USA

[4] Oakland Univ, Dept Neurosurg, William Beaumont Sch Med, Royal Oak, MI USA

[5] Oakland Univ, Dept Internal Med, William Beaumont Sch Med, Royal Oak, MI USA

[6] Div Michigan Healthcare Profess, Radiat Oncol Inst, Farmington Hills, MI USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 75卷 / 01期

关键词：

Amyloid-beta; radiation; reduction; tau; TERM NEUROCOGNITIVE OUTCOMES; ACUTE LYMPHOBLASTIC-LEUKEMIA; ALZHEIMERS-DISEASE; CRANIAL IRRADIATION; HIPPOCAMPAL NEUROGENESIS; IMPROVES COGNITION; MURINE MODEL; RADIATION; PLAQUES; IMPAIRMENT;

D O I：

10.3233/JAD-200030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-beta (A beta) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. A beta and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in A beta plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer's disease.

引用

页码：15 / 21

页数：7

共 37 条

[1] Mifepristone Alters Amyloid Precursor Protein Processing to Preclude Amyloid Beta and Also Reduces Tau Pathology [J].

Baglietto-Vargas, David ;

Medeiros, Rodrigo ;

Martinez-Coria, Hilda ;

LaFerla, Frank M. ;

Green, Kim N. .

BIOLOGICAL PSYCHIATRY, 2013, 74 (05) :357-366

[2] Tau passive immunization inhibits not only tau but also Aβ pathology [J].

Dai, Chun-ling ;

Tung, Yunn Chyn ;

Liu, Fei ;

Gong, Cheng-Xin ;

Iqbal, Khalid .

ALZHEIMERS RESEARCH & THERAPY, 2017, 9 :1-16

[3] Bone marrow drives central nervous system regeneration after radiation injury (vol 128, pg 281, 2018) [J].

Dietrich, Jorg ;

Baryawno, Ninib ;

Nayyar, Naema ;

Valtis, Yannis K. ;

Yang, Betty ;

Ly, Ina ;

Besnard, Antoine ;

Severe, Nicolas ;

Gustafsson, Karin U. ;

Andronesi, Ovidiu C. ;

Batchelor, Tracy T. ;

Sahay, Amar ;

Scadden, David T. .

JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (06) :2651-2651

[4] Long-term Neurocognitive Outcomes in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia [J].

Edelstein, Kim ;

D'Agostino, Norma ;

Bernstein, Lori J. ;

Nathan, Paul C. ;

Greenberg, Mark L. ;

Hodgson, David C. ;

Millar, Barbara Ann ;

Laperriere, Normand ;

Spiegler, Brenda J. .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2011, 33 (06) :450-458

[5] Protection of normal brain cells from γ-irradiation-induced apoptosis by a mitochondria-targeted triphenyl-phosphonium-nitroxide: a possible utility in glioblastoma therapy [J].

Huang, Zhentai ;

Jiang, Jianfei ;

Belikova, Natalia A. ;

Stoyanovsky, Detcho A. ;

Kagan, Valerian E. ;

Mintz, Arlan H. .

JOURNAL OF NEURO-ONCOLOGY, 2010, 100 (01) :1-8

[6] Ionizing radiation induces astrocyte gliosis through microglia activation [J].

Hwang, SY ;

Jung, JS ;

Kim, TH ;

Lim, SJ ;

Oh, ES ;

Kim, JY ;

Ji, KA ;

Joe, EH ;

Cho, KH ;

Han, IO .

NEUROBIOLOGY OF DISEASE, 2006, 21 (03) :457-467

[7] Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model [J].

Janczura, Karolina J. ;

Volmar, Claude-Henry ;

Sartor, Gregory C. ;

Rao, Sunil J. ;

Ricciardi, Natalie R. ;

Lambert, Guerline ;

Brothers, Shaun P. ;

Wahlestedt, Claes .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (47) :E11148-E11157

[8]

Johnson GVW, 1997, J NEUROCHEM, V68, P430

[9] EVALUATION OF COGNITIVE FUNCTION IN PATIENTS WITH LIMITED SMALL-CELL LUNG-CANCER PRIOR TO AND SHORTLY FOLLOWING PROPHYLACTIC CRANIAL IRRADIATION [J].

KOMAKI, R ;

MEYERS, CA ;

SHIN, DM ;

GARDEN, AS ;

BYRNE, K ;

NICKENS, JA ;

COX, JD .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 33 (01) :179-182

[10] Radiation therapy for tracheobronchial amyloidosis [J].

Kurrus, JA ;

Hayes, JK ;

Hoidal, JR ;

Menendez, MT ;

Elstad, MR .

CHEST, 1998, 114 (05) :1489-1492

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