The role of Toll-like receptors in periodontitis

被引：117
作者：
Song, B. [1 ,2 ]
Zhang, Y. L. [2 ]
Chen, L. J. [3 ]
Zhou, T. [1 ]
Huang, W. K. [1 ]
Zhou, X. [1 ]
Shao, L. Q. [2 ]
机构：
[1] Guizhou Prov Peoples Hosp, Guiyang, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Stomatol Hosp, Key Lab Oral Med, Guangzhou Inst Oral Dis, Guangzhou, Guangdong, Peoples R China
来源：
ORAL DISEASES | 2017年 / 23卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Toll-like receptors; periodontopathic bacteria; TLRs-mediated pathways; periodontitis; ENDOTOXIN TOLERANCE INDUCTION; GINGIVAL EPITHELIAL-CELLS; ALVEOLAR BONE LOSS; PORPHYROMONAS-GINGIVALIS; AGGREGATIBACTER-ACTINOMYCETEMCOMITANS; AGGRESSIVE PERIODONTITIS; LIGAMENT FIBROBLASTS; RHEUMATOID-ARTHRITIS; FUSOBACTERIUM-NUCLEATUM; INFLAMMATORY RESPONSES;
D O I：
10.1111/odi.12468
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Periodontitis is a common infectious disease. Recent studies have indicated that the progression of periodontitis may be regulated by interactions between host immunity and periodontopathic bacteria. Although periodontopathic bacteria can destroy periodontal tissue, a dysfunctional host immune response triggered by the bacteria can lead to more severe and persistent destruction. Toll-like receptors (TLRs), a type of pattern recognition receptor (PRR) that recognizes pathogens, have been implicated in host innate immune responses to periodontopathic bacteria and in the activation of adaptive immunity. TLR-targeted drugs may hold promise to treat periodontal disease. This review summarizes recent studies on the role of TLRs in periodontitis and discusses areas needing further research. We believe TLRs may be an effective biomarker for the prevention, diagnosis, and treatment of periodontitis in the near future.
引用
收藏
页码：168 / 180
页数：13
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