SK-ER3 neuroblastoma cells as a model for the study of estrogen influence on neural cells

被引：36

作者：

Agrati, P ^{[1
]}

Garnier, M ^{[1
]}

Patrone, C ^{[1
]}

Pollio, G ^{[1
]}

Santagati, S ^{[1
]}

Vegeto, E ^{[1
]}

Maggi, A ^{[1
]}

机构：

[1] UNIV MILAN, INST PHARMACOL SCI, CTR MPL, I-20133 MILAN, ITALY

来源：

BRAIN RESEARCH BULLETIN | 1997年 / 44卷 / 04期

关键词：

neuroblastoma; stable transfection; estrogen receptor; differentiation; brain;

D O I：

10.1016/S0361-9230(97)00237-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuroblastoma SK-ER3 cell line obtained by stable transfection of the human SK-N-BE cell line is proposed as a model for the study of estrogen receptor activity in cells of neural origin, In the SK-ER3 cell line the estrogen receptor, once activated, initiates a differentiation program leading to growth arrest, morphological changes, and acquisition of the dopaminergic phenotype, In the absence of estrogens, this program can be triggered by IGF-I, which can activate the unliganded estrogen receptor via the ras-pathway, It is proposed that this model system might recapitulate the events occurring in vivo during the differentiation of the nervous system and that IGF-I may play an important role in the activation of estrogen receptor at the very early stage of brain development affecting the differentiation of a number of hypothalamic and extrahypothalamic brain regions. (C) 1997 Elsevier Science Inc.

引用

页码：519 / 523

页数：5

共 19 条

[1] Dopaminergic phenotype induced by oestrogens in a human neuroblastoma cell line [J].

Agrati, P ;

Ma, ZQ ;

Patrone, C ;

Picotti, GB ;

Pellicciari, C ;

Bondiolotti, G ;

Bottone, MG ;

Maggi, A .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (05) :1008-1016

[2] GONADAL-STEROID INDUCTION OF STRUCTURAL SEX-DIFFERENCES IN THE CENTRAL NERVOUS-SYSTEM [J].

ARNOLD, AP ;

GORSKI, RA .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :413-442

[3] Effects of an Igf1 gene null mutation on mouse reproduction [J].

Baker, J ;

Hardy, MP ;

Zhou, J ;

Bondy, C ;

Lupu, F ;

Bellve, AR ;

Efstratiadis, A .

MOLECULAR ENDOCRINOLOGY, 1996, 10 (07) :903-918

[4] TROPHIC EFFECTS OF ESTRADIOL ON FETAL-RAT HYPOTHALAMIC NEURONS [J].

CHOWEN, JA ;

TORRESALEMAN, I ;

GARCIASEGURA, LM .

NEUROENDOCRINOLOGY, 1992, 56 (06) :895-901

[5] EVIDENCE FOR A MORPHOLOGICAL SEX DIFFERENCE WITHIN MEDIAL PREOPTIC AREA OF RAT-BRAIN [J].

GORSKI, RA ;

GORDON, JH ;

SHRYNE, JE ;

SOUTHAM, AM .

BRAIN RESEARCH, 1978, 148 (02) :333-346

[6] THE ONTOGENY OF ESTROGEN-RECEPTORS - BRAIN AND PITUITARY [J].

KEEFER, D ;

HOLDEREGGER, C .

DEVELOPMENTAL BRAIN RESEARCH, 1985, 19 (02) :183-194

[7]

LIU JP, 1993, CELL, V75, P59, DOI 10.1016/0092-8674(93)90679-K

[8]

LUSTIG RH, 1994, J NEUROSCI, V14, P3945

[9] ACTIVATED ESTROGEN-RECEPTOR MEDIATES GROWTH ARREST AND DIFFERENTIATION OF A NEUROBLASTOMA CELL-LINE [J].

MA, ZQ ;

SPREAFICO, E ;

POLLIO, G ;

SANTAGATI, S ;

CONTI, E ;

CATTANEO, E ;

MAGGI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3740-3744

[10] INSULIN-LIKE GROWTH-FACTORS ACTIVATE ESTROGEN-RECEPTOR TO CONTROL THE GROWTH AND DIFFERENTIATION OF THE HUMAN NEUROBLASTOMA CELL-LINE SK-ER3 [J].

MA, ZQ ;

SANTAGATI, S ;

PATRONE, C ;

POLLIO, G ;

VEGETO, E ;

MAGGI, A .

MOLECULAR ENDOCRINOLOGY, 1994, 8 (07) :910-918

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