The immune system view of the coronavirus SARS-CoV-2

被引：19
作者：
Celardo, Ivana [1 ]
Pace, Luigia [2 ]
Cifaldi, Loredana [3 ,4 ]
Gaudio, Carlo [1 ]
Barnaba, Vincenzo [1 ]
机构：
[1] Sapienza Univ Roma, Dipartimento Sci Clin Internist Anestesiol & Card, Rome, Italy
[2] FPO IRCCS Candiolo, Armenise Harvard Immune Regulat Unit, Italian Inst Genom Med, Turin, Italy
[3] IRCCS, Osped Pediat Bambino Gesu, Acad Dept Pediat DPUO, I-00165 Rome, Italy
[4] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, Via Montpellier 1, I-00133 Rome, Italy
来源：
BIOLOGY DIRECT | 2020年 / 15卷 / 01期
关键词：
COVID-19; SARS-CoV-2; Vaccine; Coronavirus; Monoclonal antibodies; CD8; T-CELLS; IN-VIVO; CROSS-PRESENTATION; MEMORY; VIRUS; HEPATITIS; RESPONSES; EFFECTOR; MECHANISMS; RECEPTOR;
D O I：
10.1186/s13062-020-00283-2
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Knowing the "point of view" of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsible for the Coronavirus Disease (COVID)-19. In this review, we will discuss the general host/pathogen interactions dictating protective immune response or immunopathology, addressing the role of immunity or immunopathology in influencing the clinical infection outcome, and debate the potential immunoprophylactic and immunotherapy strategies required to fight the virus infection.
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页数：11
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