Last Observation Carried Forward Versus Mixed Models in the Analysis of Psychiatric Clinical Trials

被引：191
作者：
Hamer, Robert M. [1 ]
Simpson, Pippa M. [1 ]
机构：
[1] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA
来源：
AMERICAN JOURNAL OF PSYCHIATRY | 2009年 / 166卷 / 06期
关键词：
LOCF;
D O I：
10.1176/appi.ajp.2009.09040458
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
引用
收藏
页码：639 / 641
页数：3
相关论文
共 6 条
[1]   Randomized, Double-Blind, Placebo-Controlled Study of Paliperidone Extended-Release and Quetiapine in Inpatients With Recently Exacerbated Schizophrenia [J].
Canuso, Carla M. ;
Dirks, Bryan ;
Carothers, Jennifer ;
Kosik-Gonzalez, Colette ;
Bossie, Cynthia A. ;
Zhu, Young ;
Damaraju, C. V. ;
Kalali, Amir H. ;
Mahmoud, Ramy .
AMERICAN JOURNAL OF PSYCHIATRY, 2009, 166 (06) :691-701
[2]   Handling drop-out in longitudinal clinical trials: a comparison of the LOCF and MMRM approaches [J].
Lane, Peter .
PHARMACEUTICAL STATISTICS, 2008, 7 (02) :93-106
[3]   Recommendations for the primary analysis of continuous endpoints in longitudinal clinical trials [J].
Mallinckrodt, Craig H. ;
Lane, Peter W. ;
Schnell, Dan ;
Peng, Yahong ;
Mancuso, James P. .
DRUG INFORMATION JOURNAL, 2008, 42 (04) :303-319
[4]  
SIDDIQUI O, 1998, J BIOPHARM STAT, V8, P543
[5]   MMRM vs. LOCF: A Comprehensive Comparison Based on Simulation Study and 25 NDA Datasets [J].
Siddiqui, Ohidul ;
Hung, H. M. James ;
O'Neill, Robert .
JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 2009, 19 (02) :227-246
[6]   A Semi-Parametric Shared Parameter Model to Handle Nonmonotone Nonignorable Missingness [J].
Tsonaka, Roula ;
Verbeke, Geert ;
Lesaffre, Emmanuel .
BIOMETRICS, 2009, 65 (01) :81-87
1