In vitro efficacy of Capparis spinosa extraction against larvae viability of Echinococcus granulosus sensu stricto

被引：4

作者：

Yan, Mingzhi ^{[1
,2
]}

Li, Jintian ^{[1
,2
]}

Liu, Hui ^{[1
,3
]}

Yang, Ning ^{[1
,3
]}

Chu, Jin ^{[1
,3
]}

Sun, Li ^{[1
,3
]}

Bi, Xiaojuan ^{[1
,3
]}

Lin, Renyong ^{[1
,3
,4
]}

Lv, Guodong ^{[1
,2
,3
]}

机构：

[1] Xinjiang Med Univ, Clin Med Res Inst, State Key Lab Pathogenesis Prevent & Treatment Ce, Affiliated Hosp 1, 137 Liyushan Rd, Urumqi 830054, Peoples R China

[2] Xinjiang Med Univ, Coll Pharm, Urumqi, Peoples R China

[3] Xinjiang Med Univ, WHO Collaborating Ctr Prevent & Care Management E, Affiliated Hosp 1, Urumqi, Peoples R China

[4] Xinjiang Med Univ, Basic Med Coll, Urumqi, Peoples R China

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2022年 / 84卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Capparis spinosa; cystic echinococcosis; drug development; Echinococcus granulosus sensu stricto; VIVO; PROTOSCOLECES; L;

D O I：

10.1292/jvms.21-0609

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Cystic echinococcosis (CE) is a chronic zoonotic parasitic disease caused by infection with the larvae of the Echinococcus granulosus sensu lato (s.l.) cluster. Currently, new drugs are urgently required due to the poor therapeutic effect of the existing drugs albendazole and mebendazole. Capparis spinosa, a traditional medicinal plant, has potential therapeutic effects on various diseases based on extracts from its fruit and other parts. The results of this study demonstrated that the water-soluble and ethanolic extracts of C. spinosa fruit had in vitro killing effects on the larvae of E. granulosus sensu stricto (s.s.) and disrupted the ultrastructure of protoscoleces and metacestodes. In vitro cytotoxicity assays showed that the water-soluble and ethanolic extracts of C. spinosa fruit were not significantly toxic to primary mouse hepatocytes at an effective dose to CE. In conclusion, water-soluble and ethanolic extracts of C. spinosa fruit have great potential for the development of new drugs for the treatment of CE.

引用

页码：465 / 472

页数：8

共 36 条

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