trans-10,cis-12 Conjugated linoleic acid specifically increases tissue α-tocopherol mediated by PPARγ inhibition in mice

被引：2

作者：

Wang, Ming-Shyong ^{[1
]}

Chang, Chia-Ling ^{[2
]}

Lee, Chien-I ^{[2
]}

Shaw, Huey-Mei ^{[1
]}

机构：

[1] Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan, Taiwan

[2] Chia Nan Univ Pharm & Sci, Inst Nutr & Hlth Sci, Tainan, Taiwan

来源：

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2014年 / 65卷 / 07期

关键词：

alpha-tocopherol; conjugated linoleic acid; mice; rosiglitazone; triglyceride; VITAMIN-E-DEFICIENCY; LIPOPROTEIN-LIPASE; APOLIPOPROTEIN-B; PROTEIN INSUFFICIENCY; GLUCOSE-METABOLISM; OXIDATIVE STRESS; ADIPOSE-TISSUE; C57BL/6J MICE; SECRETION; LIVER;

D O I：

10.3109/09637486.2014.917150

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

C57BL/6J mice were divided into control group (C), CLA, c9t11, or t10c12 groups. CLA and t10c12 significantly increased alpha-tocopherol levels in the plasma and various tissues in experiment 1. The CLA and t10c12 groups also showed a significant increase in hepatic alpha-tocopherol transfer protein (alpha-TTP) levels. In experiment 2, mice were divided into control, CLA, R (rosiglitazone, a PPAR gamma agonist), or CLA+ R groups. Vitamin E levels in the liver, epididymal fat pad, kidney, and plasma were increased by CLA, and this effect was reduced in the CLA+ R group. t10, c12-CLA is the most active isomer in the CLA mixture in the regulation of tissue vitamin E status and alpha-TTP protein levels in mice. The increase in liver vitamin E status in CLA-fed mice is mainly due to the effect of PPAR gamma inhibition.

引用

页码：841 / 847

页数：7

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