Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells

被引：41

作者：

Borys, Filip ^{[1
,2
,3
]}

Joachimiak, Ewa ^{[1
,2
]}

Krawczyk, Hanna ^{[3
]}

Fabczak, Hanna ^{[1
,2
]}

机构：

[1] Polish Acad Sci, Lab Cytoskeleton, 3 Pasteur St, PL-02093 Warsaw, Poland

[2] Polish Acad Sci, Cilia Biol Nencki Inst Expt Biol, 3 Pasteur St, PL-02093 Warsaw, Poland

[3] Warsaw Univ Technol, Dept Organ Chem, Fac Chem, 3 Noakowskiego St, PL-00664 Warsaw, Poland

来源：

MOLECULES | 2020年 / 25卷 / 16期

关键词：

alpha-tubulin; beta-tubulin; microtubule; post-translational modifications; cancer; microtubule-targeting agents (MTAs); tubulin-binding agents (TBAs); resistance; III BETA-TUBULIN; TO-MESENCHYMAL TRANSITION; TAXANE-BASED CHEMOTHERAPY; METASTATIC BREAST-CANCER; ALPHA-TUBULIN; LUNG-CANCER; IN-VITRO; PACLITAXEL SENSITIVITY; THERAPEUTIC TARGET; STRUCTURAL BASIS;

D O I：

10.3390/molecules25163705

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microtubules (MTs), highly dynamic structures composed of alpha- and beta-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division. Within the cell, MTs are not uniform as they can be composed of different tubulin isotypes that are post-translationally modified and interact with different microtubule-associated proteins (MAPs). These diverse intrinsic factors influence the dynamics of MTs. Extrinsic factors such as microtubule-targeting agents (MTAs) can also affect MT dynamics. MTAs can be divided into two main categories: microtubule-stabilizing agents (MSAs) and microtubule-destabilizing agents (MDAs). Thus, the MT skeleton is an important target for anticancer therapy. This review discusses factors that determine the microtubule dynamics in normal and cancer cells and describes microtubule-MTA interactions, highlighting the importance of tubulin isoform diversity and post-translational modifications in MTA responses and the consequences of such a phenomenon, including drug resistance development.

引用

页数：36

共 292 条

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