Effects of the dietary approach to stop hypertension (DASH) diet on blood pressure, blood glucose, and lipid profile in adolescents with hemophilia: A randomized clinical trial

被引:7
作者
Mahdavi, Atena [1 ,2 ]
Mohammadi, Hamed [1 ,3 ]
Foshati, Sahar [1 ,3 ]
Shokri-Mashhadi, Nafiseh [1 ,3 ]
Clark, Cain C. T. [4 ]
Moafi, Alireza [5 ]
Rouhani, Mohammad Hossein [1 ,2 ]
机构
[1] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Esfahan, Iran
[2] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran
[3] Isfahan Univ Med Sci, Dept Clin Nutr, Sch Nutr & Food Sci, Esfahan, Iran
[4] Coventry Univ, Ctr Intelligent Healthcare, Coventry, W Midlands, England
[5] Isfahan Univ Med Sci, Pediat Hematol & Oncol, Esfahan, Iran
来源
FOOD SCIENCE & NUTRITION | 2021年 / 9卷 / 01期
关键词
adolescents; blood glucose; blood pressure; dietary approach to stop hypertension; hemophilia; lipid profile; CHILDHOOD METABOLIC SYNDROME; CARDIOVASCULAR RISK; METAANALYSIS; COMORBIDITIES; CHILDREN; OBESITY; STRESS; SODIUM; FOLLOW;
D O I
10.1002/fsn3.1972
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Children with hemophilia are an enhanced risk of modifiable cardiovascular and metabolic abnormalities. There is currently no nutritional guideline to prevent or manage cardiometabolic risk factors in these patients. Therefore, the present study sought to investigate the effect of the Dietary Approaches to Stop Hypertension (DASH) diet on cardiovascular and metabolic risk factors among children with hemophilia. In this parallel randomized clinical trial, 40 children (all male) with hemophilia were randomly allocated to the DASH group (n = 20) or control group (n = 20) for 10 weeks. The intervention group received the DASH diet (50%-55% of energy from carbohydrate, 27%-30% of energy from fat and 16%-18% energy from protein), and the control group received nutritional recommendations based on healthy eating practices. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured at the beginning and end of the study. Serum vitamin C was measured as a biomarker of compliance with the DASH diet. Study was registered at IRCT.ir (IRCT20130903014551N6). A significant increase in serum vitamin C in the DASH diet group was observed compared to the control group (p = .001), indicating good compliance with the DASH diet. There was a significant reduction in SBP (-0.48 mmHg), DBP (-0.48 mmHg), FBS (-5.86 mg/dl), TC (-16.07 mg/dl), TG (-17.21 mg/dl), and LDL-C (-9.79 mg/dl), and a significant increase in HDL-C (3.39 mg/dl), in the DASH diet group compared with the control group. Adherence to the DASH diet in children with hemophilia yielded beneficial effects in blood pressure, lipid profiles, and FBS.
引用
收藏
页码:145 / 153
页数:9
相关论文
共 42 条
[41]   Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with Haemophilia [J].
Yildiz, Melek ;
Ozdemir, Nihal ;
Onal, Hasan ;
Koc, Basak ;
Tipici, Beyza Eliuz ;
Zulfikar, Bulent .
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, 2019, 11 (02) :173-180
[42]   Hemophilia: In Review [J].
Zimmerman, Bree ;
Valentino, Leonard A. .
PEDIATRICS IN REVIEW, 2013, 34 (07) :289-295