Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers

被引：30

作者：

Fukushige, Shinichi ^{[1
,2
]}

Horii, Akira ^{[1
]}

机构：

[1] Tohoku Univ, Sch Med, Dept Mol Pathol, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Sch Med, Ctr Regulatory Epigenome & Dis, Sendai, Miyagi 9808575, Japan

来源：

CANCER LETTERS | 2014年 / 342卷 / 02期

基金：

日本学术振兴会;

关键词：

DNA methylation; Early detection; miRNA; Pancreatic cancer; Satellite repeats; PAPILLARY-MUCINOUS NEOPLASMS; ABERRANT METHYLATION; GENE-EXPRESSION; INTRAEPITHELIAL NEOPLASIA; MULTIPLE GENES; CPG ISLANDS; EARLY EVENT; DNA HYPERMETHYLATION; REPRESSORS ZEB1; DOWN-REGULATION;

D O I：

10.1016/j.canlet.2012.03.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognosis of pancreatic cancer is extremely poor, mainly because of its aggressive biological behavior and late onset of symptoms for clinical diagnosis; these impose limitations on therapeutic intervention. Deeper genomic sequencing analyses of pancreatic cancers revealed 12 core pathways and a long duration, nearly 20 years from initiation to distant metastases. This evidence will offer a broader aspect and time window of opportunity for early detection, thus preventing deaths from this cruel cancer. Epigenetic biomarkers can be utilized for assessing cancer risk, early detection, and predicting prognosis and therapeutic responses. In this review, we briefly summarize relevant issues associated with pancreatic cancer progression and recent advances in epigenetic biomarkers such as DNA methylation, miRNAs, satellite repeats, and histone modifications for early diagnosis. (C) 2012 Published by Elsevier Ireland Ltd.

引用

页码：231 / 237

页数：7

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