Mechanisms of Glucocorticoid-Induced Insulin Resistance Focus on Adipose Tissue Function and Lipid Metabolism

被引：283

作者：

Geer, Eliza B. ^{[1
]}

Islam, Julie ^{[2
]}

Buettner, Christoph ^{[1
]}

机构：

[1] Mt Sinai Med Ctr, Div Endocrinol, New York, NY 10029 USA

[2] Beth Israel Deaconess Med Ctr, Div Endocrinol & Metab, New York, NY 10003 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 01期

关键词：

Glucocorticoids; Cushing syndrome; Adipose tissue; Lipolysis; Lipids; Insulin resistance; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; TUMOR-NECROSIS-FACTOR; DE-NOVO LIPOGENESIS; MAGNETIC-RESONANCE-SPECTROSCOPY; NONALCOHOLIC HEPATIC STEATOSIS; SPLANCHNIC CORTISOL PRODUCTION; ENDOGENOUS CUSHINGS-SYNDROME; HORMONE-SENSITIVE LIPASE;

D O I：

10.1016/j.ecl.2013.10.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoids (GCs) are critical in the regulation of the stress response, inflammation and energy homeostasis. Excessive GC exposure results in whole-body insulin resistance, obesity, cardiovascular disease, and ultimately decreased survival, despite their potent anti-inflammatory effects. This apparent paradox may be explained by the complex actions of GCs on adipose tissue functionality. The wide prevalence of oral GC therapy makes their adverse systemic effects an important yet incompletely understood clinical problem. This article reviews the mechanisms by which supraphysiologic GC exposure promotes insulin resistance, focusing in particular on the effects on adipose tissue function and lipid metabolism.

引用

页码：75 / +

页数：29

共 215 条

[1] Biomarkers of hypothalamic-pituitary-adrenal axis activity in mice lacking 11β-HSD1 and H6PDH [J].

Abrahams, Lianne ;

Semjonous, Nina M. ;

Guest, Phil ;

Zielinska, Agnieszka ;

Hughes, Beverly ;

Lavery, Gareth G. ;

Stewart, Paul M. .

JOURNAL OF ENDOCRINOLOGY, 2012, 214 (03) :367-372

[2] Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence [J].

Adam, Emma K. ;

Doane, Leah D. ;

Zinbarg, Richard E. ;

Mineka, Susan ;

Craske, Michelle G. ;

Griffith, James W. .

PSYCHONEUROENDOCRINOLOGY, 2010, 35 (06) :921-931

[3] Cortisol Is Negatively Associated with Insulin Sensitivity in Overweight Latino Youth [J].

Adam, Tanja C. ;

Hasson, Rebecca E. ;

Ventura, Emily E. ;

Toledo-Corral, Claudia ;

Le, Kim-Ann ;

Mahurkar, Swapna ;

Lane, Christianne J. ;

Weigensberg, Marc J. ;

Goran, Michael I. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (10) :4729-4735

[4] A Switch in Hepatic Cortisol Metabolism across the Spectrum of Non Alcoholic Fatty Liver Disease [J].

Ahmed, Adeeba ;

Rabbitt, Elizabeth ;

Brady, Theresa ;

Brown, Claire ;

Guest, Peter ;

Bujalska, Iwona J. ;

Doig, Craig ;

Newsome, Philip N. ;

Hubscher, Stefan ;

Elias, Elwyn ;

Adams, David H. ;

Tomlinson, Jeremy W. ;

Stewart, Paul M. .

PLOS ONE, 2012, 7 (02)

[5] Type 2 diabetes and metabolic syndrome are associated with increased expression of 11β-hydroxysteroid dehydrogenase 1 in obese subjects [J].

Alberti, L. ;

Girola, A. ;

Gilardini, L. ;

Conti, A. ;

Cattaldo, S. ;

Micheletto, G. ;

Invitti, C. .

INTERNATIONAL JOURNAL OF OBESITY, 2007, 31 (12) :1826-1831

[6] Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice [J].

Alberts, P ;

Engblom, L ;

Edling, N ;

Forsgren, M ;

Klingström, G ;

Larsson, C ;

Rönquist-Nii, Y ;

Öhman, B ;

Abrahmsén, L .

DIABETOLOGIA, 2002, 45 (11) :1528-1532

[7] Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice [J].

Almind, Katrine ;

Manieri, Monia ;

Sivitz, William I. ;

Cinti, Saverio ;

Kahn, C. Ronald .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (07) :2366-2371

[8] THE EFFECTS OF GLUCOCORTICOIDS ON INSULIN-STIMULATED LIPOGENESIS IN PRIMARY CULTURES OF RAT HEPATOCYTES [J].

AMATRUDA, JM ;

DANAHY, SA ;

CHANG, CL .

BIOCHEMICAL JOURNAL, 1983, 212 (01) :135-141

[9] The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis [J].

Anagnostis, Panagiotis ;

Athyros, Vasilios G. ;

Tziomalos, Konstantinos ;

Karagiannis, Asterios ;

Mikhailidis, Dimitri P. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (08) :2692-2701

[10] Effects of the 11β-hydroxysteroid dehydrogrenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes [J].

Andrews, RC ;

Rooyackers, O ;

Walker, BR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :285-291

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