The role of NDRG1 in the pathology and potential treatment of human cancers

被引：88

作者：

Bae, Dong-Hun ^{[1
,2
]}

Jansson, Patric J. ^{[1
,2
]}

Huang, Michael L. ^{[1
,2
]}

Kovacevic, Zaklina ^{[1
,2
]}

Kalinowski, Danuta ^{[1
,2
]}

Lee, C. Soon ^{[3
,4
,5
,6
]}

Sahni, Sumit ^{[1
,2
]}

Richardson, Des R. ^{[1
,2
]}

机构：

[1] Univ Sydney, Mol Pharmacol & Pathol Program, Dept Pathol, Sydney, NSW 2006, Australia

[2] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia

[3] Univ Western Sydney, Sch Med, Discipline Pathol, Sydney, NSW, Australia

[4] Univ Western Sydney, Sch Med, Mol Med Res Grp, Sydney, NSW, Australia

[5] Univ Sydney, Canc Pathol Bosch Inst, Sydney, NSW 2006, Australia

[6] Ingham Inst Appl Med Res, Canc Pathol & Cell Biol Lab, Sydney, NSW, Australia

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2013年 / 66卷 / 11期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

METASTASIS; IRON; CANCER RESEARCH; DOWNSTREAM-REGULATED GENE-1; METASTASIS SUPPRESSOR GENE; SELECTIVE ANTITUMOR-ACTIVITY; SQUAMOUS-CELL CARCINOMA; N-MYC; IRON CHELATORS; PROSTATE-CANCER; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; TUMOR-METASTASIS;

D O I：

10.1136/jclinpath-2013-201692

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

N-myc downstream regulated gene 1 (NDRG1) has been well characterised to act as a metastatic suppressor in a number of human cancers. It has also been implicated to have a significant function in a number of physiological processes such as cellular differentiation and cell cycle. In this review, we discuss the role of NDRG1 in cancer pathology. NDRG1 was observed to be downregulated in the majority of cancers. Moreover, the expression of NDRG1 was found to be significantly lower in neoplastic tissues as compared with normal tissues. The most important function of NDRG1 in inhibiting tumour progression is associated with its ability to suppress metastasis. However, it has also been shown to have important effects on other stages of cancer progression (primary tumour growth and angiogenesis). Recently, novel iron chelators with selective antitumour activity (ie, Dp44mT, DpC) were shown to upregulate NDRG1 in cancer cells. Moreover, Dp44mT showed its antimetastatic potential only in cells expressing NDRG1, making this protein an important therapeutic target for cancer chemotherapy. This observation has led to increased interest in the examination of these novel anticancer agents.

引用

页码：911 / 917

页数：7

共 85 条

[1] N-myc downstream regulated gene1/Cap43 overexpression suppresses tumor growth by hepatic cancer cells through cell cycle arrest at the G0/G1 phase [J].