Apoptosis-independent functions of killer caspases

被引：106
作者：
Algeciras-Schimnich, A [1 ]
Barnhart, BC [1 ]
Peter, ME [1 ]
机构：
[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2002年 / 14卷 / 06期
关键词：
D O I：
10.1016/S0955-0674(02)00384-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.
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收藏
页码：721 / 726
页数：6
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