Predictors of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma: a case report

被引：10

作者：

Cattelan, Anna Maria ^{[2
]}

Mattiolo, Adriana ^{[1
]}

Grassi, Angela ^{[1
]}

Piano, Maria Assunta ^{[1
]}

Sasset, Lolita ^{[3
]}

Trevenzoli, Marco ^{[4
]}

Zanovello, Paola ^{[5
]}

Calabro, Maria Luisa ^{[1
]}

机构：

[1] IOV IRCCS, Veneto Inst Oncol, Immunol & Mol Oncol, Padua, Italy

[2] Azienda Osped & Univ Padova, Infect & Trop Dis, Padua, Italy

[3] ULSS 18 Azienda Osped, Infect Dis, Rovigo, Italy

[4] Univ Padua, Sch Med, Dept Infect & Trop Dis, Padua, Italy

[5] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy

来源：

INFECTIOUS AGENTS AND CANCER | 2016年 / 11卷

关键词：

Immune reconstitution inflammatory syndrome; IRIS; Kaposi's sarcoma; KS; KS-IRIS; HHV8; KSHV; Biomarker; ANTIRETROVIRAL THERAPY; BIOMARKERS;

D O I：

10.1186/s13027-016-0051-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naive AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (>6 log(10) genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors.

引用

页数：4

共 14 条

[1] Biomarkers of HIV immune reconstitution inflammatory syndrome [J].

Bonham, Shuli ;

Meya, David B. ;

Bohjanen, Paul R. ;

Boulware, David R. .

BIOMARKERS IN MEDICINE, 2008, 2 (04) :349-361

[2] Evaluation of Plasma Human Herpesvirus 8 DNA as a Marker of Clinical Outcomes during Antiretroviral Therapy for AIDS-Related Kaposi Sarcoma in Zimbabwe [J].

Borok, Margaret ;

Fiorillo, Suzanne ;

Gudza, Ivy ;

Putnam, Beverly ;

Ndemera, Buxton ;

White, Irene E. ;

Gwanzura, Lovemore ;

Schooley, Robert T. ;

Campbell, Thomas B. .

CLINICAL INFECTIOUS DISEASES, 2010, 51 (03) :342-349

[3] The effect of HAART in 254 consecutive patients with AIDS-related Kaposi's sarcoma [J].

Bower, Mark ;

Weir, Justin ;

Francis, Nicholas ;

Newsom-Davis, Tom ;

Powles, Sam ;

Crook, Tim ;

Boffito, Marta ;

Gazzard, Brian ;

Nelson, Mark .

AIDS, 2009, 23 (13) :1701-1706

[4]

Cattelan AM, 2005, INT J ONCOL, V27, P779

[5]

Cattelan Anna Maria, 2000, Journal of the National Cancer Institute Monographs, P44, DOI 10.1093/oxfordjournals.jncimonographs.a024256

[6] Comparing an individual's test score against norms derived from small samples [J].

Crawford, JR ;

Howell, DC .

CLINICAL NEUROPSYCHOLOGIST, 1998, 12 (04) :482-486

[7] Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma [J].

Feller L. ;

Lemmer J. .

Infectious Agents and Cancer, 3 (1)

[8] Immune restoration disease after antiretroviral therapy [J].

French, MA ;

Price, P ;

Stone, SF .

AIDS, 2004, 18 (12) :1615-1627

[9] Use of a BJAB-derived cell line for isolation of human herpesvirus 8 [J].

Gasperini, P ;

Barbierato, M ;

Martinelli, C ;

Rigotti, P ;

Marchini, F ;

Masserizzi, G ;

Leoncini, F ;

Chieco-Bianchi, L ;

Schulz, TF ;

Calabrò, ML .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (06) :2866-2875

[10] AIDS-related Kaposi's sarcoma: Prospective validation of the AIDS Clinical Trials Group staging classification [J].

Krown, SE ;

Testa, MA ;

Huang, J .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (09) :3085-3092

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