Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes

被引：8

作者：

Hernandez-Mijares, Antonio ^{[1
,2
,3
,4
]}

Banuls, Celia ^{[1
,2
,3
]}

Rovira-Llopis, Susana ^{[1
,2
,3
]}

Alvarez, Angeles ^{[5
,6
]}

Orden, Samuel ^{[5
,6
]}

Rubio-Puchol, Olalla ^{[2
]}

Victor, Victor M. ^{[1
,2
,3
,5
,7
]}

Rocha, Milagros ^{[1
,2
,3
,5
]}

机构：

[1] Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46020, Spain

[2] Univ Hosp Dr Peset, Serv Endocrinol, Valencia 46017, Spain

[3] Inst Hlth Res INCLIVA, Valencia 46010, Spain

[4] Univ Valencia, Fac Med, Dept Med, Valencia 46010, Spain

[5] Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia 46010, Spain

[6] Univ Valencia, Fac Med, Dept Pharmacol, Valencia 46010, Spain

[7] Univ Valencia, Fac Med, Dept Physiol, Valencia 46010, Spain

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 18卷

关键词：

Type; 2; diabetes; Inositol; Inflammation; Endothelial function; Oxidative stress; D-CHIRO-INOSITOL; IMPROVES METABOLIC-CONTROL; CARDIOVASCULAR RISK; ARABINOXYLAN FIBER; INSULIN ACTION; PINITOL;

D O I：

10.1016/j.jff.2015.08.025

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The anti-diabetic properties of an inositol-enriched beverage (IEB) on the endothelial function and redox status in diabetic subjects were assessed. This was a 12-week, double-blind randomized controlled trial employing thirty-eight diabetic subjects that were divided into two intervention groups: one receiving an IEB and the other a sucrose-enriched beverage. Subjects consuming IEB exhibited a significant decrease in triacylglycerol (8.82%) and HbA1c (4.53%) levels. Continuous glucose monitoring revealed a significant net reduction of 2.51 and 7.11% during postprandial and overnight fasting periods after consumption of IEB, respectively. Moreover, IEB improved endothelial function by reducing P-selectin levels and leucocyte-endothelium interactions, as there was an increase in rolling velocity and a reduction in polymorphonuclear leucocyte adhesion and induced a significant diminution in the generation of ROS. The present results show that IEB supplementation induces a significant improvement in glycaemic control in diabetic subjects by improving endothelial function and intracellular redox status. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：598 / 607

页数：10

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