Central mediation of the effects of interleukin-1 on social exploration and body weight in mice

被引：54

作者：

Bluthe, RM ^{[1
]}

Dantzer, R ^{[1
]}

Kelley, KW ^{[1
]}

机构：

[1] UNIV ILLINOIS, IMMUNOPHYSIOL LAB, URBANA, IL 61801 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 1997年 / 22卷 / 01期

关键词：

interleukin-1; interleukin-1 receptor antagonist; receptor; social behavior; body weight; mouse;

D O I：

10.1016/S0306-4530(96)00042-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To study the role of central IL-1 receptors in the effects of recombinant human IL-1 beta (IL-1 beta) on behavior and body weight, intracerebroventricular (ICV) injection of the specific antagonist of IL-1 receptors, IL-1ra, was administered to mice injected intraperitoneally (IP) and ICV with various doses of IL-1 beta. Doses of 500 ng IP IL-1 beta and 900 pg ICV IL-1 beta induced a comparable decrease in social behavior and loss of body weight. Pretreatment with IL-1ra (1.8 mu g/mouse, ICV) blocked the effects of ICV IL-1 beta (900 pg/mouse) on social behavior. ICV IL-1ra (3.6 mu g/mouse) also attenuated the effects of IP IL-1 beta (500 ng/mouse) on social behavior and change in body weight, suggesting that the effects of peripheral IL-1 beta are centrally mediated. (C) 1997 Elsevier Science Ltd.

引用

页码：1 / 11

页数：11

共 45 条

[1] INTERLEUKIN-1 RECEPTOR ANTAGONIST - A NEW MEMBER OF THE INTERLEUKIN-1 FAMILY [J].

AREND, WP .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (05) :1445-1451

[2] PROSTAGLANDIN-E2 AND COLLAGENASE PRODUCTION BY FIBROBLASTS AND SYNOVIAL-CELLS IS REGULATED BY URINE-DERIVED HUMAN INTERLEUKIN-1 AND INHIBITOR(S) [J].

BALAVOINE, JF ;

DEROCHEMONTEIX, B ;

WILLIAMSON, K ;

SECKINGER, P ;

CRUCHAUD, A ;

DAYER, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (04) :1120-1124

[3] Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally [J].

Bluthe, RM ;

Michaud, B ;

Kelley, KW ;

Dantzer, R .

NEUROREPORT, 1996, 7 (09) :1485-1488

[4]

BLUTHE RM, 1994, CR ACAD SCI III-VIE, V317, P499

[5]

BLUTHE RM, 1989, NEUROSCI RES COMMUN, V5, P149

[6]

BLUTHE RM, 1991, NEUROSCI RES COMMUN, V9, P151

[7] DIFFERENTIAL-EFFECTS OF IL-1RA ON SICKNESS BEHAVIOR AND WEIGHT-LOSS INDUCED BY IL-1 IN RATS [J].

BLUTHE, RM ;

BEAUDU, C ;

KELLEY, KW ;

DANTZER, R .

BRAIN RESEARCH, 1995, 677 (01) :171-176

[8] PURIFICATION, CLONING, EXPRESSION AND BIOLOGICAL CHARACTERIZATION OF AN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN [J].

CARTER, DB ;

DEIBEL, MR ;

DUNN, CJ ;

TOMICH, CSC ;

LABORDE, AL ;

SLIGHTOM, JL ;

BERGER, AE ;

BIENKOWSKI, MJ ;

SUN, FF ;

MCEWAN, RN ;

HARRIS, PKW ;

YEM, AW ;

WASZAK, GA ;

CHOSAY, JG ;

SIEU, LC ;

HARDEE, MM ;

ZURCHERNEELY, HA ;

REARDON, IM ;

HEINRIKSON, RL ;

TRUESDELL, SE ;

SHELLY, JA ;

EESSALU, TE ;

TAYLOR, BM ;

TRACEY, DE .

NATURE, 1990, 344 (6267) :633-638

[9] 18TH FORUM IN IMMUNOLOGY - INTERLEUKIN-1 [J].

CAVAILLON, JM ;

HAEFFNERCAVAILLON, N ;

AURON, PE ;

WEBB, AC ;

DURUM, SK ;

BRODY, DT ;

TARTAKOVSKY, B ;

MATSUSHIMA, K ;

AKAHOSHI, T ;

OPPENHEIM, JJ ;

MACDONALD, HR ;

LOWENTHAL, JW ;

SECKINGER, P ;

DAYER, JM ;

UNANUE, ER ;

WEAVER, CT ;

FUHLBRIGGE, RC ;

KIELY, JM ;

CHAPLIN, DD ;

BORASCHI, D ;

ANTONI, G ;

TAGLIABUE, A ;

YAMASHITA, U ;

LACHMAN, LB ;

BAKOUCHE, O ;

KLEINERMAN, ES ;

CYBULSKY, MI ;

MOVAT, HZ ;

DINARELLO, CA .

ANNALES DE L INSTITUT PASTEUR-IMMUNOLOGY, 1987, 138 (03) :461-516

[10] THE TYPE-II DECOY RECEPTOR - A NOVEL REGULATORY PATHWAY FOR INTERLEUKIN-1 [J].

COLOTTA, F ;

DOWER, SK ;

SIMS, JE ;

MANTOVANI, A .

IMMUNOLOGY TODAY, 1994, 15 (12) :562-566

← 1 2 3 4 5 →