Mycosynthesis of novel lactone in foliar endophytic fungus isolated from Bixa orellana L.

被引：4

作者：

Vijayakumar, Sujithra ^{[1
]}

Raj, Rajani ^{[2
]}

Shaanker, Uma ^{[2
]}

Sivaramakrishna, Akella ^{[3
]}

Ramamoorthy, Siva ^{[1
]}

机构：

[1] VIT, Sch Bio Sci & Technol, Vellore 632014, Tamil Nadu, India

[2] Univ Agr Sci, Dept Crop Physiol, Bangalore 560065, Karnataka, India

[3] VIT, Sch Adv Sci, Vellore 632014, Tamil Nadu, India

来源：

3 BIOTECH | 2021年 / 11卷 / 01期

关键词：

Dye yielding plant; Fusarium verticillioides; Red pigment; Secondary metabolite; Symbiont; BIOLOGICAL-ACTIVITIES; GENE; IDENTIFICATION; BIOSYNTHESIS; DIVERSITY; PIGMENT; METABOLITES; TOXICITY; ACHIOTE; PROTEIN;

D O I：

10.1007/s13205-020-02566-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

There is a colossal demand for natural pigments and its applications in recent times. In the study, a novel lactone pigment was isolated from a predominant endophytic fungus residing in Bixa orellana L. (Bixaceae) leaves. The endophyte was identified as Fusarium verticillioides through morphological and molecular investigations. The optimum growth parameters of the endophyte for pigment production were at 33 oC with pH 6.5 in dark. Through comprehensive spectroscopic studies, the structure of the isolated lactone was resolved and identified as (E)-3, 3-dimethyl-4-(pent-1-en-1-yl)-4-propyldihydrofuran-2(3H)-one. The acute oral toxicity study of the pigment investigated upon female Wistar rats indicated the median lethal dose (LD50) value above 1000 mg/kg body weight affirming safety. Thus, the red pigment from the isolated endophyte may be employed as a sustainable source for natural colorant in industries owing to its non-toxicity.

引用

页数：15

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