Research advances on arachidonic acid production by fermentation and genetic modification of Mortierella alpina

被引：20

作者：

Zhang, Huidan ^{[1
]}

Cui, Qiu ^{[1
]}

Song, Xiaojin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shandong Prov Key Lab Energy Genet, CAS Key Lab Biofuels,Qingdao Inst Bioenergy & Bio, Shandong Engn Lab Single Cell Oil,Qingdao Engn La, 189 Songling Rd, Qingdao 266101, Shandong, Peoples R China

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2021年 / 37卷 / 01期

关键词：

Arachidonic acid; Biosynthesis; Environmental conditions; Metabolic engineering strategy; Mortierella alpine; OIL-PRODUCING FUNGUS; FED-BATCH CULTURE; OLEAGINOUS FUNGUS; LIPID-METABOLISM; POTENTIAL SOURCE; MALIC ENZYME; TRANSFORMATION; 1S-4; RICH; PH;

D O I：

10.1007/s11274-020-02984-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Arachidonic acid (ARA, 5, 8, 11, 14-cis-eicosatetraenoic acid) is a relevant omega -6 polyunsaturated fatty acid, which plays essential roles in human immune, cardiovascular, and nervous systems. It is widely used in medicine, cosmetics, nutrition, and other fields. Traditionally, ARA is obtained from animal tissues. However, due to the limitation and unsustainability of existing resources, microorganisms are a potential alternative resource for ARA production. In this regard, major efforts have been made on algae and filamentous fungi, among which Mortierella alpina is the most effective strain for industrial ARA production. In this review, we summarized the recent progress in enhancing M. alpina production by optimization of culture medium and fermentation process and genetic modification. In addition, we provided perspectives in synthetic biology methods and technologies to further increase ARA production.

引用

页数：9

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