A receptor in pituitary and hypothalamus that functions in growth hormone release

被引：1696

作者：

Howard, AD

Feighner, SD

Cully, DF

Arena, JP

Liberator, PA

Rosenblum, CI

Hamelin, M

Hreniuk, DL

Palyha, OC

Anderson, J

Paress, PS

Diaz, C

Chou, M

Liu, KK

McKee, KK

Pong, SS

Chaung, LY

Elbrecht, A

Dashkevicz, M

Heavens, R

Rigby, M

Sirinathsinghji, DJS

Dean, DC

Melillo, DG

Patchett, AA

Nargund, R

Griffin, PR

DeMartino, JA

Gupta, SK

Schaeffer, JM

Smith, RG

VanderPloeg, LHT

机构：

[1] MERCK RES LABS,RAHWAY,NJ 07065

[2] MERCK SHARP & DOHME LTD,NEUROSCI RES CTR,HARLOW CM20 2QR,ESSEX,ENGLAND

来源：

SCIENCE | 1996年 / 273卷 / 5277期

关键词：

D O I：

10.1126/science.273.5277.974

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.

引用

页码：974 / 977

页数：4

共 31 条

[1] EXPRESSION OF A GLUTAMATE-ACTIVATED CHLORIDE CURRENT IN XENOPUS-OOCYTES INJECTED WITH CAENORHABDITIS-ELEGANS RNA - EVIDENCE FOR MODULATION BY AVERMECTIN [J].