Association of Body Mass Index with the Tuberculosis Infection: a Population-based Study among 17796 Adults in Rural China

被引：25

作者：

Zhang, Haoran ^{[1
,2
,3
]}

Li, Xiangwei ^{[1
,2
,3
]}

Xin, Henan ^{[1
,2
,3
]}

Li, Hengjing ^{[1
,2
,3
]}

Li, Mufei ^{[1
,2
,3
]}

Lu, Wei ^{[4
]}

Bai, Liqiong ^{[5
]}

Wang, Xinhua ^{[6
]}

Liu, Jianmin ^{[7
]}

Jin, Qi ^{[1
,2
,3
]}

Gao, Lei ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Pathogen Biol, MOH Key Lab Syst Biol Pathogens, Beijing 100730, Peoples R China

[2] Chinese Acad Med Sci, Ctr TB, Beijing 100730, Peoples R China

[3] Peking Union Med Coll, Beijing 100730, Peoples R China

[4] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China

[5] Hunan Prov Inst TB Prevent & Control, Changsha 410006, Hunan, Peoples R China

[6] Gansu Prov Ctr Dis Control & Prevent, Lanzhou 730000, Peoples R China

[7] Sixth Peoples Hosp Zhengzhou, Zhengzhou 450061, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

RISK; OBESITY; LEPTIN; IMPACT;

D O I：

10.1038/srep41933

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Body mass index (BMI) has been shown to be associated with host susceptibility to several infections. However, the link between BMI and the risk of tuberculosis (TB) infection has been sparsely studied in China and in worldwide. Based on the baseline survey of a population-based, prospective study in rural China, the association between BMI and TB infection among adults was estimated by means of cross-sectional analysis. TB infection status was tested using QuantiFERON-TB Gold In-Tube (QFT), a commercial of interferon-gamma release assay (IGRA). Totally, 17796 eligible participants aged >= 18 years from 4 study sites, were included in the analysis. 21.76% (3873/17796) were observed to be QFT positive. Age and gender standardized prevalence ranged from 16.49% to 23.81% across the study sites. 42.19% study participants were obese/overweight with BMI >= 24.0 kg/m(2). BMI >= 28.0 kg/m(2) was observed to be independently associated with QFT positivity (adjusted odds ratio: 1.17, 95% confidence interval: 1.04-1.33). The strength of the association was found to be geographically diversity, which might be explained, at least partly, by the varied local TB epidemic status. Our results suggest that individuals with obesity might be one important target population for TB infection control in rural China.

引用

页数：9

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