AXIN1 and AXIN2 variants in gastrointestinal cancers

被引：111

作者：

Mazzoni, Serina M. ^{[1
]}

Fearon, Eric R. ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

CANCER LETTERS | 2014年 / 355卷 / 01期

关键词：

Wnt signaling; Beta-catenin; Colon cancer; Hepatocellular carcinoma; Gastric cancer; WNT SIGNALING PATHWAY; ADENOMATOUS POLYPOSIS-COLI; APC TUMOR-SUPPRESSOR; BETA-CATENIN; NEGATIVE REGULATOR; COLORECTAL-CANCER; HEPATOCELLULAR CARCINOMAS; PROTEIN INTERACTIONS; SEQUENCE VARIANTS; GENETIC-VARIATION;

D O I：

10.1016/j.canlet.2014.09.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic and familial CRCs can be explained by mutations in APC or other genes with well-established roles in CRC. The AXIN1 and AXIN2 proteins function in the canonical Wnt pathway, and AXIN1/2 alterations have been proposed as key defects in some cancers. Here, we review AXIN1 and AXIN2 sequence alterations reported in gastrointestinal cancers, with the goal of vetting the evidence that some of the variants may have key functional roles in cancer development. (C) 2014 Published by Elsevier Ireland Ltd.

引用

页码：1 / 8

页数：8

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