Synthesis of amphiphilic polyethylene-b-poly(L-glutamate) block copolymers with vastly different solubilities and their stimuli-responsive polymeric micelles in aqueous solution

被引：25

作者：

Gao, Haiyang ^{[1
]}

Li, Guiliang ^{[1
]}

Hu, Zhilong ^{[1
]}

Xiao, Zefan ^{[1
]}

Liang, Guodong ^{[1
]}

Wu, Qing ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, DSAPM Lab, PCFM Lab, Guangzhou 510275, Guangdong, Peoples R China

来源：

POLYMER | 2014年 / 55卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Block copolymer; Self-assembly; Polyethylene; ONE-POT SYNTHESIS; LIVING POLYMERIZATION; NICKEL-CATALYST; LINEAR POLYETHYLENE; TRIBLOCK COPOLYMERS; TRANSITION; VESICLES; ETHYLENE; DIBLOCK; CORE;

D O I：

10.1016/j.polymer.2014.07.019

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This paper describes the synthesis, characterization, and self-assembly behavior of amphiphilic polyethylene-block-poly(L-glutamate) (PE-b-PGA) diblock copolymers. PE-b-PGA diblock copolymers were obtained by ring-opening polymerization (ROP) of gamma-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) using PE COOCH(Pr-i)NH2 as a macroinitiator and subsequent deprotection of the benzylester groups. The self-assembly behaviors of the PE-b-PGA copolymers in water were studied as a function of pH and ionic strength by means of fluorescence spectroscopy, laser light scattering, UV-circular dichroism, and transmission electron microscopy. The size of the polymeric micelles decreases with a decreasing pH value even at high salt concentrations because the solvating PGA units can perform a coil-to-helix transition. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4593 / 4600

页数：8

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