Synthesis of amphiphilic polyethylene-b-poly(L-glutamate) block copolymers with vastly different solubilities and their stimuli-responsive polymeric micelles in aqueous solution

被引：25

作者：

Gao, Haiyang ^{[1
]}

Li, Guiliang ^{[1
]}

Hu, Zhilong ^{[1
]}

Xiao, Zefan ^{[1
]}

Liang, Guodong ^{[1
]}

Wu, Qing ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, DSAPM Lab, PCFM Lab, Guangzhou 510275, Guangdong, Peoples R China

来源：

POLYMER | 2014年 / 55卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Block copolymer; Self-assembly; Polyethylene; ONE-POT SYNTHESIS; LIVING POLYMERIZATION; NICKEL-CATALYST; LINEAR POLYETHYLENE; TRIBLOCK COPOLYMERS; TRANSITION; VESICLES; ETHYLENE; DIBLOCK; CORE;

D O I：

10.1016/j.polymer.2014.07.019

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This paper describes the synthesis, characterization, and self-assembly behavior of amphiphilic polyethylene-block-poly(L-glutamate) (PE-b-PGA) diblock copolymers. PE-b-PGA diblock copolymers were obtained by ring-opening polymerization (ROP) of gamma-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) using PE COOCH(Pr-i)NH2 as a macroinitiator and subsequent deprotection of the benzylester groups. The self-assembly behaviors of the PE-b-PGA copolymers in water were studied as a function of pH and ionic strength by means of fluorescence spectroscopy, laser light scattering, UV-circular dichroism, and transmission electron microscopy. The size of the polymeric micelles decreases with a decreasing pH value even at high salt concentrations because the solvating PGA units can perform a coil-to-helix transition. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4593 / 4600

页数：8

共 53 条

[1]

[Anonymous], 2010, FUEL CELLS B, V2010, P5

[2] Electromechanical limits of polymersomes [J].

Aranda-Espinoza, H ;

Bermudez, H ;

Bates, FS ;

Discher, DE .

PHYSICAL REVIEW LETTERS, 2001, 87 (20) :208301-1

[3] POLYPEPTIDES .3. THE SYNTHESIS OF HIGH MOLECULAR WEIGHT POLY-GAMMA-BENZYL-L-GLUTAMATES [J].

BLOUT, ER ;

KARLSON, RH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1956, 78 (05) :941-946

[4] Bioinspired functional block copolymers [J].

Boerner, Hans G. ;

Schlaad, Helmut .

SOFT MATTER, 2007, 3 (04) :394-408

[5] Synthesis of ABA triblock copolymers via acyclic diene metathesis polymerization and living polymerization of α-amino acid-N-carboxyanhydrides [J].

Brzezinska, KR ;

Deming, TJ .

MACROMOLECULES, 2001, 34 (13) :4348-4354

[6] Structure of polypeptide-based diblock copolymers in solution:: Stimuli-responsive vesicles and micelles [J].

Chécot, F ;

Brûlet, A ;

Oberdisse, J ;

Gnanou, Y ;

Mondain-Monval, O ;

Lecommandoux, S .

LANGMUIR, 2005, 21 (10) :4308-4315

[7]

Chécot F, 2002, ANGEW CHEM INT EDIT, V41, P1339, DOI 10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO

[8]

2-N

[9] From supramolecular polymersomes to stimuli-responsive nano-capsules based on poly(diene-b-peptide) diblock copolymers [J].

Chécot, F ;

Lecommandoux, S ;

Klok, HA ;

Gnanou, Y .

EUROPEAN PHYSICAL JOURNAL E, 2003, 10 (01) :25-35

[10] Transition metal-catalyzed one-pot synthesis of water-soluble dendritic molecular nanocarriers [J].

Chen, GH ;

Guan, ZB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (09) :2662-2663

← 1 2 3 4 5 6 →