A Water-Soluble Copper(II) Complex for the Selective Fluorescence Detection of Nitric Oxide/Nitroxyl and Imaging in Living Cells

被引：33

作者：

Sun, Xiaolong ^{[1
]}

Kim, Gyoungmi ^{[2
]}

Xu, Yufang ^{[3
]}

Yoon, Juyoung ^{[2
]}

James, Tony D. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

[3] E China Univ Sci & Technol, Sch Pharm, Meilong Rd 130, Shanghai 200237, Peoples R China

来源：

CHEMPLUSCHEM | 2016年 / 81卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

cell imaging; copper; fluorescence probes; nitric oxide; nitroxyl; DEHYDROASCORBIC ACID; OXIDE PRODUCTION; AQUEOUS-SOLUTION; PROBE; 4,5-DIAMINOFLUORESCEIN; NITROXYL; SENSITIVITY; SYSTEM; NO;

D O I：

10.1002/cplu.201500436

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells.

引用

收藏

页码：30 / 34

页数：5

相关论文

共 23 条

[1] Detection of Nitric Oxide and Nitroxyl with Benzoresorufin-Based Fluorescent Sensors [J].

Apfel, Ulf-Peter ;

Buccella, Daniela ;

Wilson, Justin J. ;

Lippard, Stephen J. .

INORGANIC CHEMISTRY, 2013, 52 (06) :3285-3294

[2] Redox Proteomics: Chemical Principles, Methodological Approaches and Biological/Biomedical Promises [J].

Bachi, Angela ;

Dalle-Donne, Isabella ;

Scaloni, Andrea .

CHEMICAL REVIEWS, 2013, 113 (01) :596-698

[3] Photoactivation and calcium sensitivity of the fluorescent NO indicator 4,5-diaminofluorescein (DAF-2): implications for cellular NO imaging [J].

Broillet, MC ;

Randin, O ;

Chatton, JY .

FEBS LETTERS, 2001, 491 (03) :227-232

[4]

Chatton JY, 2002, METHOD ENZYMOL, V359, P134

[5] Highly sensitive fluorescence probes for nitric oxide based on boron dipyrromethene chromophore-rational design of potentially useful bioimaging fluorescence probe [J].

Gabe, Y ;

Urano, Y ;

Kikuchi, K ;

Kojima, H ;

Nagano, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (10) :3357-3367

[6] A Reductant-Resistant and Metal-Free Fluorescent Probe for Nitroxyl Applicable to Living Cells [J].

Kawai, Kodai ;

Ieda, Naoya ;

Aizawa, Kazuyuki ;

Suzuki, Takayoshi ;

Miyata, Naoki ;

Nakagawa, Hidehiko .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (34) :12690-12696

[7] Nitroxyl (HNO): A Novel Redox Signaling Molecule [J].

Kemp-Harper, Barbara K. .

ANTIOXIDANTS & REDOX SIGNALING, 2011, 14 (09) :1609-1613

[8]

Knott AB, 2009, ANTIOXID REDOX SIGN, V11, P541, DOI [10.1089/ars.2008.2234, 10.1089/ARS.2008.2234]

[9] Metal-based turn-on fluorescent probes for sensing nitric oxide [J].

Lim, Mi Hee ;

Lippard, Stephen J. .

ACCOUNTS OF CHEMICAL RESEARCH, 2007, 40 (01) :41-51

[10] Direct nitric oxide detection in aqueous solution by copper(II) fluorescein complexes [J].

Lim, Mi Hee ;

Wong, Brian A. ;

Pitcock, William H., Jr. ;

Mokshagundam, Deepa ;

Baik, Mu-Hyun ;

Lippard, Stephen J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (44) :14364-14373