Anti-M-Induced Delayed Hemolytic Transfusion Reaction

被引：9

作者：

Fadeyi, Emmanuel A. ^{[1
,2
]}

Naal, Tawfeq ^{[1
,2
]}

Green, Mary ^{[1
,2
]}

Simmons, Julie H. ^{[2
]}

Jones, Mary Rose ^{[2
]}

Pomper, Gregory J. ^{[1
,2
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol & Lab Med, Winston Salem, NC 27109 USA

[2] Wake Forest Baptist Hlth, Dept Pathol & Lab Med, Winston Salem, NC 27157 USA

来源：

LABORATORY MEDICINE | 2020年 / 51卷 / 04期

关键词：

anti-IgG; anti-IgM; anti-M; direct antiglobulin test; delayed hemolytic transfusion reaction; red blood cell transfusions;

D O I：

10.1093/labmed/lmz078

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Anti-M is most often assumed to be naturally occurring and can be comprised of a mixture of predominantly immunoglobulin(Ig)M with a lesser IgG component. Anti-M-antibodies usually do not react at 37 degrees C and therefore are considered to be of little clinical significance. Methods: A 28-year-old man presented with hemorrhagic shock from numerous injuries sustained in a motor vehicle collision. The patient received several units of red blood cells (RBCs). The antibody screen, the direct antiglobulin test (DAT), and the RBC genotype were sent for laboratory evaluation. Results: A total of 12 days after the first antibody screening result was negative (7 days after transfusion), the lowest hemoglobin value was 5.5 g per dL, and we observed a positive antibody screening result and DAT with immunoglobulin (Ig)G anti-M identified. After transfusion of 4 units of M antigen-negative RBC, the post-transfusion hemoglobin level increased to 8.9 g per dL. Conclusion: Obtaining M antigen-negative compatible RBCs is necessary in patients demonstrating IgG anti-M in plasma.

引用

页码：426 / 429

页数：4