Association of Interferon Gamma Gene Polymorphisms With BK Virus Infection Among Hispanic Renal Allograft Recipients

被引:16
作者
Vu, Don [1 ,2 ,3 ]
Sakharkar, Prashant [3 ]
Shah, Tariq [2 ,3 ,4 ,5 ]
Naraghi, Robert [2 ,4 ]
Yasir, Qazi [5 ]
Hutchinson, Ian [1 ,5 ]
Min, David [2 ,3 ]
机构
[1] Mendez Natl Inst Transplantat, Los Angeles, CA USA
[2] St Vincents Med Ctr, Los Angeles, CA USA
[3] Western Univ Hlth Sci, Coll Pharm, Pomona, CA 91766 USA
[4] Transplant Res Inst, Los Angeles, CA USA
[5] Univ So Calif, Los Angeles, CA USA
关键词
BK virus nephropathy; Kidney allograft; Gene polymorphism; Interferon gamma; POLYOMAVIRUS-ASSOCIATED NEPHROPATHY; KIDNEY-TRANSPLANT; IFN-GAMMA; INTERSTITIAL NEPHRITIS; CYCLOSPORINE-A; VIRAL LOAD; REPLICATION; IMMUNOSUPPRESSION; EXPRESSION; DISEASE;
D O I
10.1097/01.TP.0000438115.20198.89
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background BK virus nephropathy is one of the most common viral infections that affect up to 10% of renal transplant recipients (RTRs), causing allograft dysfunction and graft loss. Interferon-gamma (IFN-) gene polymorphisms have been associated with parvovirus B19, hepatitis C virus, HIV-1/AIDS infection, cytomegalovirus viremia, and disease. IFN- is known to have potent inhibitory effects on BK virus gene expression, both at the level of transcription and translation. Methods It was investigated whether IFN- polymorphisms are associated with BKV infection. Genotyping of four single-nucleotide polymorphisms located in the IFN- gene were performed on DNA collected from a total of 251 RTRs (71 RTRs with BKV infection and 180 without BKV infection). Results Analysis of the results showed that IFN- (rs12369470) CC genotype was significantly associated with susceptibility to BKV infection (OR: 2.9, 95% CI: 1.29-6.44, P=0.007) while the IFN- +874 (rs2435061) TT and (rs2406918) CC genotypes appear to be markers for protection against BKV infection (OR: 0.29, 95% CI: 0.1-0.83, P=0.01 for rs245061; OR: 0.61, 95% CI: 0.4-0.94, P=0.02 for rs24069718). A haplotype analysis using the combination of rs2435061-rs2406918-rs2870953 showed that the A-G-T haplotype was associated with a significantly reduced risk for BKV infection (OR: 0.43, 95% CI: 0.25-0.73, P=0.001). Conclusion Polymorphisms in the IFN- gene may confer certain protection or predisposition for BKV infection.
引用
收藏
页码:660 / 667
页数:8
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