Modulating Aβ33-42 Peptide Assembly by Graphene Oxide

被引：72
作者：
Li, Qiang [1 ]
Liu, Lei [1 ,2 ]
Zhang, Shuai [1 ]
Xu, Meng [3 ]
Wang, Xueqin [1 ]
Wang, Chen [3 ]
Besenbacher, Flemming [1 ]
Dong, Mingdong [1 ]
机构：
[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark
[2] JiangSu Univ, Inst Adv Mat, Zhenjiang 212013, Peoples R China
[3] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 24期
关键词：
amyloid peptides; assembly; graphene oxide; modulated structures; ATOMIC-FORCE MICROSCOPY; BETA-AMYLOID FIBRILS; PROTEIN FIBRILLATION; CARBON NANOTUBE; POLYMERIC NANOPARTICLES; NANOMATERIALS; INHIBITION; GRAPHITE; DISEASE; CYTOTOXICITY;
D O I：
10.1002/chem.201402022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Graphene oxide (GO) is utilized as the modulator to tune the formation and development of amyloid fibrils (A beta(33-42)). Atomic force microscopy temporal evolution measurements reveal that the initial binding between the peptide monomer and the large available surface of the GO sheets can redirect the assembly pathway of amyloid beta. The results support the possibility to develop graphene-based materials to inhibit amyloidosis.
引用
收藏
页码：7236 / 7240
页数：5
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