Prenatal and peripubertal phthalates and bisphenol A in relation to sex hormones and puberty in boys

被引：113

作者：

Ferguson, Kelly K. ^{[1
]}

Peterson, Karen E. ^{[1
,2
,3
]}

Lee, Joyce M. ^{[1
,4
,5
]}

Mercado-Garcia, Adriana ^{[6
]}

Blank-Goldenberg, Clara ^{[7
]}

Tellez-Rojo, Martha M. ^{[6
]}

Meeker, John D. ^{[1
]}

机构：

[1] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[4] Univ Michigan, Child Hlth Evaluat & Res Unit, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Ann Arbor, MI 48109 USA

[6] Natl Inst Publ Hlth, Ctr Evaluat Res & Surveys, Div Stat, Cuernavaca, Morelos, Mexico

[7] Amer British Chowdray ABC Hosp, Mexico City, DF, Mexico

来源：

REPRODUCTIVE TOXICOLOGY | 2014年 / 47卷

基金：

美国国家卫生研究院;

关键词：

Environment; Exposure; Testosterone; Puberty; Tanner stage; Bisphenol A; IN-UTERO EXPOSURE; ANOGENITAL DISTANCE; TESTOSTERONE PRODUCTION; DI(N-BUTYL) PHTHALATE; HEALTH; RAT; TESTES; SERUM; PREGNANCY; CHILDREN;

D O I：

10.1016/j.reprotox.2014.06.002

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phthalates and BPA are known endocrine disruptors and exposure in pregnant mothers and children is ubiquitous. We explored the relationship of prenatal and childhood exposures with pubertal onset and sex hormones in boys (ages 8-14). Phthalate metabolites and BPA were measured in maternal 3rd trimester or childhood urine. Sex hormones DHEAS, estradiol, inhibin B, SHBG, and total testosterone were measured in serum. Adrenarche and puberty were assessed by pediatrician. Prenatal exposure to some phthalates was associated with decreased DHEAS and inhibin B levels, and with increased SHBG. Prenatal exposure to most phthalates and BPA was associated with greatly reduced odds of adrenarche (odds ratios [OR] = 0.12-0.65) and slightly reduced odds of puberty (OR=0.50-0.98). Childhood exposure was not associated with adrenarche or puberty, but some phthalates and BPA were associated with increased SHBG levels and decreased total and free testosterone levels. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：70 / 76

页数：7

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