This work describes the petrogenesis of in situ and in-source trondhjemite leucosomes generated by low-degree partial melting of the Jurassic Cheshmeh-Ghasaban hornblende-gabbros in the northern Alvand batholith (Hamedan, NW Iran). These leucosomes occur in a metatexite migmatite as patches, net-structures, veinlets, and dikes at scales ranging from a few millimetres to a few metres. They have high SiO2 (mean approximate to 78 wt%) and Na2O (4-5 wt%) with low Al2O3 (<15 wt%), K2O (<1.5 wt%), Sr (33-267 ppm), Eu (0.31-0.62 ppm) and heavy REE (<4 ppm) contents similar to typical low-Al2O3 trondhjemites. Batch-melting models indicate these leucosomes are the result of approximate to 1-2% partial melting of the hornblende-gabbro, whereas thermobarometric modelling constrains their petrogenesis in the field of hornblende hornfels-facies metamorphism (pressure approximate to 3.0-4.5 kbar and temperature approximate to 700-750 degrees C). On a wider scale, our results document natural trondhjemites generated in the upper crust by amphibole-dehydration melting of a mafic source at temperature conditions close to the solidus, filling the existing gap of data in low-pressure (P < 5kbar) and low-temperature (T < 800 degrees C) amphibole-dominated partial melting experiments. The genesis of these trondhjemites is then discussed with respect to the Mesozoic evolution of the Alvand plutonic complex.