γ-Aminobutyric acid (GABA) signalling in plants

被引:256
|
作者
Ramesh, Sunita A. [1 ,2 ]
Tyerman, Stephen D. [1 ,2 ]
Gilliham, Matthew [1 ,2 ]
Xu, Bo [1 ,2 ]
机构
[1] Univ Adelaide, Plant Transport & Signalling Lab, ARC Ctr Excellence Plant Energy Biol, Glen Osmond, SA 5064, Australia
[2] Univ Adelaide, Sch Agr Food & Wine, Waite Res Inst, Glen Osmond, SA 5064, Australia
基金
澳大利亚研究理事会;
关键词
gamma-Aminobutyric acid; Aluminium-activated malate transporters; GABA(A) receptors; Signalling; GABA metabolism; Carbon-nitrogen balance; Stress response; Topology; Pharmacology; POLLEN-TUBE GROWTH; SUCCINIC-SEMIALDEHYDE-DEHYDROGENASE; AMINO BUTYRIC-ACID; SOLANUM-LYCOPERSICON L; GATED CHLORIDE CHANNEL; AGONIST BINDING-SITE; TRITICUM-AESTIVUM L; GLUTAMATE-DECARBOXYLASE; ANION-CHANNEL; SALT STRESS;
D O I
10.1007/s00018-016-2415-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The role of gamma-aminobutyric acid (GABA) as a signal in animals has been documented for over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the last 15 years, and it was not until last year that a mechanism by which this could occur was identified-a plant 'GABA receptor' that inhibits anion passage through the aluminium-activated malate transporter family of proteins (ALMTs). ALMTs are multigenic, expressed in different organs and present on different membranes. We propose GABA regulation of ALMT activity could function as a signal that modulates plant growth, development, and stress response. In this review, we compare and contrast the plant 'GABA receptor' with mammalian GABA(A) receptors in terms of their molecular identity, predicted topology, mode of action, and signalling roles. We also explore the implications of the discovery that GABA modulates anion flux in plants, its role in signal transduction for the regulation of plant physiology, and predict the possibility that there are other GABA interaction sites in the N termini of ALMT proteins through in silico evolutionary coupling analysis; we also explore the potential interactions between GABA and other signalling molecules.
引用
收藏
页码:1577 / 1603
页数:27
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