13-Deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus

被引：8
作者：
Gverzdys, Tomas [1 ]
Hart, Michael Kamin [2 ]
Pimentel-Elardo, Sheila [1 ]
Tranmer, Geoffrey [2 ]
Nodwell, Justin R. [1 ]
机构：
[1] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada
[2] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada
来源：
JOURNAL OF ANTIBIOTICS | 2015年 / 68卷 / 11期
关键词：
STREPTOMYCES-NASHVILLENSIS MJ885-MF8; COMPLETE GENOME SEQUENCE; ANTIMICROBIAL ANTIBIOTICS; TETRODECAMYCIN; DIHYDROTETRODECAMYCIN; DISCOVERY; REVEALS; CLUSTER; GENE;
D O I：
10.1038/ja.2015.60
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
WAC04657 is a wild-isolate Streptomyces that has antibiotic activities against multidrug-resistant Gram-negative and Gram-positive pathogens. From a solid-agar culture of this organism we isolated 13-deoxytetrodecamycin, a novel antibacterial molecule. It is one of at least three distinct antimicrobial compounds produced by this strain. The molecule has the molecular formula C18H22O5 and is related to the previously discovered compound tetrodecamycin. 13-Deoxytetrodecamycin has potent bioactivity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus.
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收藏
页码：698 / 702
页数：5
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