The future of personalised radiotherapy for head and neck cancer

被引：168

作者：

Caudell, Jimmy J. ^{[1
]}

Torres-Roca, Javier F. ^{[1
]}

Gillies, Robert J. ^{[2
]}

Enderling, Heiko ^{[3
]}

Kim, Sungjune ^{[1
]}

Rishi, Anupam ^{[1
]}

Moros, Eduardo G. ^{[1
]}

Harrison, Louis B. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, Tampa, FL USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Imaging & Metab, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, Tampa, FL USA

来源：

LANCET ONCOLOGY | 2017年 / 18卷 / 05期

关键词：

STEREOTACTIC BODY RADIOTHERAPY; TEXTURE ANALYSIS; RADIATION; HYPOXIA; EXPRESSION; TOXICITY; IMPACT; CELLS; TRIAL; LUNG;

D O I：

10.1016/S1470-2045(17)30252-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiotherapy has long been the mainstay of treatment for patients with head and neck cancer and has traditionally involved a stage-dependent strategy whereby all patients with the same TNM stage receive the same therapy. We believe there is a substantial opportunity to improve radiotherapy delivery beyond just technological and anatomical precision. In this Series paper, we explore several new ideas that could improve understanding of the phenotypic and genotypic differences that exist between patients and their tumours. We discuss how exploiting these differences and taking advantage of precision medicine tools-such as genomics, radiomics, and mathematical modelling-could open new doors to personalised radiotherapy adaptation and treatment. We propose a new treatment shift that moves away from an era of empirical dosing and fractionation to an era focused on the development of evidence to guide personalisation and biological adaptation of radiotherapy. We believe these approaches offer the potential to improve outcomes and reduce toxicity.

引用

页码：E266 / E273

页数：8

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