Vibrational spectroscopy: a clinical tool for cancer diagnostics

被引:261
作者
Kendall, Catherine [1 ]
Isabelle, Martin [1 ]
Bazant-Hegemark, Florian [1 ]
Hutchings, Joanne [1 ]
Orr, Linda [1 ]
Babrah, Jaspreet [1 ]
Baker, Rebecca [1 ]
Stone, Nicholas [1 ]
机构
[1] Gloucestershire Royal Hosp, NHS Fdn Trust, Biophoton Res Unit, Gloucester GL1 3NN, England
基金
美国国家卫生研究院;
关键词
INFRARED RAMAN-SPECTROSCOPY; FT-IR MICROSPECTROSCOPY; BASAL-CELL CARCINOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; FIBER-OPTIC PROBES; IN-VIVO; BREAST-CANCER; PRINCIPAL COMPONENT; PROSTATE-CANCER; HUMAN TISSUE;
D O I
10.1039/b822130h
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Vibrational spectroscopy techniques have demonstrated potential to provide non-destructive, rapid, clinically relevant diagnostic information. Early detection is the most important factor in the prevention of cancer. Raman and infrared spectroscopy enable the biochemical signatures from biological tissues to be extracted and analysed. In conjunction with advanced chemometrics such measurements can contribute to the diagnostic assessment of biological material. This paper also illustrates the complementary advantage of using Raman and FTIR spectroscopy technologies together. Clinical requirements are increasingly met by technological developments which show promise to become a clinical reality. This review summarises recent advances in vibrational spectroscopy and their impact on the diagnosis of cancer.
引用
收藏
页码:1029 / 1045
页数:17
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