Synthesis and application of quinazoline-oxazoline-containing (quinazox) ligands

被引：49

作者：

Fekner, Tomasz ^{[1
]}

Muller-Bunz, Helge ^{[1
]}

Guiry, Patrick J. ^{[1
]}

机构：

[1] Univ Coll Dublin, Ctr Synthesis & Chem Biol, Sch Chem & Chem Biol, Dublin 4, Ireland

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 22期

关键词：

D O I：

10.1021/ol062023+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of potentially tridentate P,N,N-ligands containing two stereogenic elements incorporated into the axially chiral Quinazolinap and centrally chiral 2-oxazoline subunits is reported. The application of these novel hybrid ligands in Pd(0)-catalyzed asymmetric allylic alkylation revealed the matched and mismatched diastereomer, dominant stereogenic element, as well as the effect of the oxazoline R substituent on the level of enantioselectivity (ee's up to 81%).

引用

页码：5109 / 5112

页数：4

共 44 条

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