Camelid genomes reveal evolution and adaptation to desert environments

被引：237

作者：

Wu, Huiguang ^{[1
]}

Guang, Xuanmin ^{[2
]}

Al-Fageeh, Mohamed B. ^{[3
]}

Cao, Junwei ^{[1
]}

Pan, Shengkai ^{[2
]}

Zhou, Huanmin ^{[1
]}

Zhang, Li ^{[1
]}

Abutarboush, Mohammed H. ^{[3
]}

Xing, Yanping ^{[1
]}

Xie, Zhiyuan ^{[2
]}

Alshanqeeti, Ali S. ^{[3
]}

Zhang, Yanru ^{[1
]}

Yao, Qiulin ^{[2
]}

Al-Shomrani, Badr M. ^{[3
]}

Zhang, Dong ^{[1
]}

Li, Jiang ^{[2
]}

Manee, Manee M. ^{[3
]}

Yang, Zili ^{[1
]}

Yang, Linfeng ^{[2
]}

Liu, Yiyi ^{[1
]}

Zhang, Jilin ^{[2
]}

Altammami, Musaad A. ^{[3
]}

Wang, Shenyuan ^{[1
]}

Yu, Lili ^{[2
]}

Zhang, Wenbin ^{[4
]}

Liu, Sanyang ^{[2
]}

Ba, La ^{[4
]}

Liu, Chunxia ^{[1
]}

Yang, Xukui ^{[2
]}

Meng, Fanhua ^{[1
]}

Wang, Shaowei ^{[2
]}

Li, Lu ^{[1
]}

Li, Erli ^{[2
]}

Li, Xueqiong ^{[1
]}

Wu, Kaifeng ^{[1
]}

Zhang, Shu ^{[2
]}

Wang, Junyi ^{[2
]}

Yin, Ye ^{[2
]}

Yang, Huanming ^{[2
]}

Al-Swailem, Abdulaziz M. ^{[3
]}

Wang, Jun ^{[2
,5
,6
]}

机构：

[1] Inner Mongolia Agr Univ, Coll Life Sci, Hohhot 010018, Peoples R China

[2] BGI Shenzhen, Shenzhen 518083, Peoples R China

[3] KACST, Natl Biotechnol Ctr, Riyadh 11442, Saudi Arabia

[4] Inst Bactrian Camels, Alxa League 750306, Inner Mongolia, Peoples R China

[5] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

[6] King Abdulaziz Univ, Jeddah 21589, Saudi Arabia

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

关键词：

MIDDLE PLEISTOCENE TRANSITION; ENHANCER-BINDING PROTEIN; SEQUENCE; DATABASE; PHYLOGENIES; ALIGNMENT; INSULIN; GENES; PREDICTION; ALGORITHM;

D O I：

10.1038/ncomms6188

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bactrian camel (Camelus bactrianus), dromedary (Camelus dromedarius) and alpaca (Vicugna pacos) are economically important livestock. Although the Bactrian camel and dromedary are large, typically arid-desert-adapted mammals, alpacas are adapted to plateaus. Here we present high-quality genome sequences of these three species. Our analysis reveals the demographic history of these species since the Tortonian Stage of the Miocene and uncovers a striking correlation between large fluctuations in population size and geological time boundaries. Comparative genomic analysis reveals complex features related to desert adaptations, including fat and water metabolism, stress responses to heat, aridity, intense ultraviolet radiation and choking dust. Transcriptomic analysis of Bactrian camels further reveals unique osmoregulation, osmoprotection and compensatory mechanisms for water reservation underpinned by high blood glucose levels. We hypothesize that these physiological mechanisms represent kidney evolutionary adaptations to the desert environment. This study advances our understanding of camelid evolution and the adaptation of camels to arid-desert environments.

引用

页数：9

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