Switchable electrooxidative N-methyl amines: access to C3-aminomethylated and C3-arylmethylated imidazo[1,2-a] pyridines

被引：13

作者：

Li, Sifeng ^{[1
]}

Wang, Taimin ^{[1
]}

Li, Xingchen ^{[1
]}

Fang, Lijing ^{[2
]}

Zhai, Hongbin ^{[1
,3
]}

Cheng, Bin ^{[1
]}

机构：

[1] Shenzhen Polytech, Inst Marine Biomed, Postdoctoral Innovat Practice Base, 7098 Liuxian Ave, Shenzhen 518055, Peoples R China

[2] Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, 1068 Xueyuan Ave, Shenzhen 518055, Peoples R China

[3] Peking Univ, Sch Chem Biol & Biotechnol, Lab Chem Genom, Shenzhen Grad Sch, 2199 Lishui Rd, Shenzhen 518055, Peoples R China

来源：

GREEN CHEMISTRY | 2022年 / 24卷 / 24期

关键词：

C-H BOND; TERTIARY-AMINES; OXIDATION; ANILINES; TETRAHYDROQUINOLINES; FUNCTIONALIZATION; IMIDAZOPYRIDINES; METHYLANILINES; CYCLIZATION; MALEIMIDES;

D O I：

10.1039/d2gc03464f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Switchable approaches to accomplish the C3-aminomethylation and C3-arylmethylation of imidazo[1,2-a]pyridines with N-methylanilines using distinct electrochemical conditions have been developed. These two transformations exhibited notable regio- and chemoselectivities under air and metal/oxidant-free conditions. Remarkably, the environmentally benign electrochemical methods could be extended to the late-stage derivatization of natural products and drugs using N-methyl amines as a 1C source.

引用

页码：9482 / 9488

页数：7

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