Coming Full Circle-From Endless Complexity to Simplicity and Back Again

被引：194
作者：
Weinberg, Robert A. [1 ,2 ,3 ]
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] Ludwig MIT Ctr Mol Oncol, Cambridge, MA 02142 USA
[3] MIT, Dept Biol, Cambridge, MA 02142 USA
来源：
CELL | 2014年 / 157卷 / 01期
关键词：
DEPENDENT DNA-POLYMERASE; HUMAN BLADDER; TRANSFORMING GENE; CELL-LINES; MUTAGENS; CARCINOGENS; ACTIVATION; ONCOGENES; VIRIONS; HARVEY;
D O I：
10.1016/j.cell.2014.03.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell has celebrated the powers of reductionist molecular biology and its major successes for four decades. Those who have participated in cancer research during this period have witnessed wild fluctuations from times where endless inexplicable phenomenology reigned supreme to periods of reductionist triumphalism
引用
收藏
页码：267 / 271
页数：5
相关论文
共 31 条
[1]   IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS [J].
AMES, BN ;
LEE, FD ;
DURSTON, WE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :782-786
[2]   VIRAL RNA-DEPENDENT DNA POLYMERASE - RNA-DEPENDENT DNA POLYMERASE IN VIRIONS OF RNA TUMOUR VIRUSES [J].
BALTIMORE, D .
NATURE, 1970, 226 (5252) :1209-+
[3]   ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].
BARRESINOUSSI, F ;
CHERMANN, JC ;
REY, F ;
NUGEYRE, MT ;
CHAMARET, S ;
GRUEST, J ;
DAUGUET, C ;
AXLERBLIN, C ;
VEZINETBRUN, F ;
ROUZIOUX, C ;
ROZENBAUM, W ;
MONTAGNIER, L .
SCIENCE, 1983, 220 (4599) :868-871
[4]   CELLULAR ONCOGENES AND RETROVIRUSES [J].
BISHOP, JM .
ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :301-354
[5]  
Cairns J., 1978, CANC SCI SOC
[6]   ANALYSIS OF 2 DIVERGENT RAT GENOMIC CLONES HOMOLOGOUS TO THE TRANSFORMING GENE OF HARVEY MURINE SARCOMA-VIRUS [J].
DEFEO, D ;
GONDA, MA ;
YOUNG, HA ;
CHANG, EH ;
LOWY, DR ;
SCOLNICK, EM ;
ELLIS, RW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3328-3332
[7]   TRANSFORMING GENES OF HUMAN BLADDER AND LUNG-CARCINOMA CELL-LINES ARE HOMOLOGOUS TO THE RAS GENES OF HARVEY AND KIRSTEN SARCOMA-VIRUSES [J].
DER, CJ ;
KRONTIRIS, TG ;
COOPER, GM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11) :3637-3640
[8]   Outcome signature genes in breast cancer: is there a unique set? [J].
Ein-Dor, L ;
Kela, I ;
Getz, G ;
Givol, D ;
Domany, E .
BIOINFORMATICS, 2005, 21 (02) :171-178
[9]   Concordance among gene-expression-based predictors for breast cancer [J].
Fan, Cheng ;
Oh, Daniel S. ;
Wessels, Lodewyk ;
Weigelt, Britta ;
Nuyten, Dimitry S. A. ;
Nobel, Andrew B. ;
van't Veer, Laura J. ;
Perou, Charles M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (06) :560-569
[10]   A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].
FEARON, ER ;
VOGELSTEIN, B .
CELL, 1990, 61 (05) :759-767
1234