Wortmannin, an ihibitor of DNA double-strand break rejoining, sensitizes human cells to radiation but protects against the cytotoxic effect of cisplatin: Relevance for radiochemotherapy?

被引：1
|
作者：
Frankenberg-Schwager, M [1 ]
Garg, I [1 ]
Gregus, A [1 ]
Neumann, C [1 ]
Penninggers, H [1 ]
Pralle, E [1 ]
Frankenberg, DS [1 ]
机构：
[1] Univ Gottingen, D-37075 Gottingen, Germany
来源：
RADIOTHERAPY AND ONCOLOGY | 2006年 / 78卷
关键词：
D O I：
10.1016/S0167-8140(06)80629-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
150
引用
收藏
页码：S50 / S50
页数：1
相关论文
共 50 条
  • [1] RADIATION-INDUCED DNA DOUBLE-STRAND BREAK REJOINING IN HUMAN TUMOR-CELLS
    NUNEZ, MI
    VILLALOBOS, M
    OLEA, N
    VALENZUELA, MT
    PEDRAZA, V
    MCMILLAN, TJ
    DEALMODOVAR, JMR
    BRITISH JOURNAL OF CANCER, 1995, 71 (02) : 311 - 316
  • [2] Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks
    Chernikova, SB
    Wells, RL
    Elkind, MM
    RADIATION RESEARCH, 1999, 151 (02) : 159 - 166
  • [3] DNA double-strand break rejoining in human follicular lymphoma and glioblastoma tumor cells
    Macann, AMJ
    Britten, RA
    Poppema, S
    Pearcey, R
    Rosenberg, E
    Allalunis-Turner, MJ
    Murray, D
    ONCOLOGY REPORTS, 2000, 7 (02) : 299 - 303
  • [4] DNA double-strand break rejoining rates, inherent radiation sensitivity and human tumour response to radiotherapy
    Schwartz, JL
    Mustafi, R
    Beckett, MA
    Weichselbaum, RR
    BRITISH JOURNAL OF CANCER, 1996, 74 (01) : 37 - 42
  • [5] Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells
    Rief, N
    Löbrich, M
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (23) : 20572 - 20582
  • [6] A DNA Double-Strand Break Kinetic Rejoining Model Based on the Local Effect Model
    Tommasino, F.
    Friedrich, T.
    Scholz, U.
    Taucher-Scholz, G.
    Durante, M.
    Scholz, M.
    RADIATION RESEARCH, 2013, 180 (05) : 524 - 538
  • [7] DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells
    Pluth, Janice M.
    Yamazaki, Vikky
    Cooper, Brian A.
    Rydberg, Bjorn E.
    Kirchgessner, Cordula U.
    Cooper, Priscilla K.
    DNA REPAIR, 2008, 7 (01) : 108 - 118
  • [8] Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair
    Alonso-Gonzalez, Carolina
    Gonzalez, Alicia
    Martinez-Campa, Carlos
    Gomez-Arozamena, Jose
    Cos, Samuel
    JOURNAL OF PINEAL RESEARCH, 2015, 58 (02) : 189 - 197
  • [9] Radiation-induced DNA double-strand breaks and rejoining in malignant glioma cells
    Ozawa, T
    Wang, J
    Lamborn, KR
    Deen, DF
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1999, 75 (05) : 563 - 570
  • [10] Influence of DNA double-strand break rejoining on clonogenic survival and micronucleus yield in human cell lines
    Akudugu, JM
    Theron, T
    Serafin, AA
    Böhm, L
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2004, 80 (02) : 93 - 104
12345