Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

被引：379

作者：

Wen, Haitao ^{[1
]}

Miao, Edward A. ^{[1
,2
]}

Ting, Jenny P. -Y. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Lineberger Canc Res Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

IMMUNITY | 2013年 / 39卷 / 03期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; THIOREDOXIN-INTERACTING PROTEIN; INNATE IMMUNE DETECTION; LINKS OXIDATIVE STRESS; NLRP3; INFLAMMASOME; CUTTING EDGE; HOST-DEFENSE; IL-1-BETA SECRETION; COLON INFLAMMATION;

D O I：

10.1016/j.immuni.2013.08.037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.

引用

页码：432 / 441

页数：10

共 111 条

[1] Caspase-11 Protects Against Bacteria That Escape the Vacuole [J].

Aachoui, Youssef ;

Leaf, Irina A. ;

Hagar, Jon A. ;

Fontana, Mary F. ;

Campos, Cristine G. ;

Zak, Daniel E. ;

Tan, Michael H. ;

Cotter, Peggy A. ;

Vance, Russell E. ;

Aderem, Alan ;

Miao, Edward A. .

SCIENCE, 2013, 339 (6122) :975-978

[2] Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage [J].

Ali, Syed Raza ;

Timmer, Anjuli M. ;

Bilgrami, Sameera ;

Park, Eek Joong ;

Eckmann, Lars ;

Nizet, Victor ;

Karin, Michael .

IMMUNITY, 2011, 35 (01) :34-44

[3] NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling [J].

Allen, Irving C. ;

Wilson, Justin E. ;

Schneider, Monika ;

Lich, John D. ;

Roberts, Reid A. ;

Arthur, Janelle C. ;

Woodford, Rita-Marie T. ;

Davis, Beckley K. ;

Uronis, Joshua M. ;

Herfarth, Hans H. ;

Jobin, Christian ;

Rogers, Arlin B. ;

Ting, Jenny P. -Y. .

IMMUNITY, 2012, 36 (05) :742-754

[4] NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens [J].

Anand, Paras K. ;

Malireddi, R. K. Subbarao ;

Lukens, John R. ;

Vogel, Peter ;

Bertin, John ;

Lamkanfi, Mohamed ;

Kanneganti, Thirumala-Devi .

NATURE, 2012, 488 (7411) :389-+

[5] Anthrax Lethal Toxin Induced Lysosomal Membrane Permeabilization and Cytosolic Cathepsin Release Is Nlrp1b/Nalp1b-Dependent [J].

Averette, Kathleen M. ;

Pratt, Matthew R. ;

Yang, Yanan ;

Bassilian, Sara ;

Whitelegge, Julian P. ;

Loo, Joseph A. ;

Muir, Tom W. ;

Bradley, Kenneth A. .

PLOS ONE, 2009, 4 (11)

[6] Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome [J].

Bauernfeind, Franz ;

Bartok, Eva ;

Rieger, Anna ;

Franchi, Luigi ;

Nunez, Gabriel ;

Hornung, Veit .

JOURNAL OF IMMUNOLOGY, 2011, 187 (02) :613-617

[7] Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner [J].

Bossaller, Lukas ;

Chiang, Ping-I ;

Schmidt-Lauber, Christian ;

Ganesan, Sandhya ;

Kaiser, William J. ;

Rathinam, Vijay A. K. ;

Mocarski, Edward S. ;

Subramanian, Deepa ;

Green, Douglas R. ;

Silverman, Neal ;

Fitzgerald, Katherine A. ;

Marshak-Rothstein, Ann ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2012, 189 (12) :5508-5512

[8] Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin [J].

Boyden, ED ;

Dietrich, WF .

NATURE GENETICS, 2006, 38 (02) :240-244

[9] Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1β and IL-1α from murine macrophages [J].

Brough, D ;

Le Feuvre, RA ;

Wheeler, RD ;

Solovyova, N ;

Hilfiker, S ;

Rothwell, NJ ;

Verkhratsky, A .

JOURNAL OF IMMUNOLOGY, 2003, 170 (06) :3029-3036

[10] Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 [J].

Broz, Petr ;

Ruby, Thomas ;

Belhocine, Kamila ;

Bouley, Donna M. ;

Kayagaki, Nobuhiko ;

Dixit, Vishva M. ;

Monack, Denise M. .

NATURE, 2012, 490 (7419) :288-+

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