Caffeine alters plasma adenosine levels

被引：100
|
作者：
Conlay, LA
Conant, JA
deBros, F
Wurtman, R
机构：
[1] HARVARD UNIV,SCH MED,BOSTON,MA 02114
[2] MIT,LAB NEUROENDOCRINE REGULAT,E25 617,CAMBRIDGE,MA 02139
来源：
NATURE | 1997年 / 389卷 / 6647期
关键词：
D O I：
10.1038/38160
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Since the delights of tea were discovered by Emperor Shen Nung in 2737 BC, methylxanthines have been common in the human diet. Today, the methylxanthine caffeineis the most commonly consumed drug in the world1, with actions mediated primarily by adenosine receptor blockade2. We now report that caffeine increases plasma adenosine concentration in a manner that is dose-related, saturable, and mimicked by peripheral adenosine receptor blockade. Opposite effects are seen after caffeine withdrawal, indicative of a receptor-mediated effect.
引用
收藏
页码：136 / 136
页数：1
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