Beyond cardiovascular medicine: potential future uses of icosapent ethyl

被引：10

作者：

Bhatt, Deepak L. ^{[1
,2
]}

Hull, Mark A. ^{[3
]}

Song, Mingyang ^{[4
,5
,6
,7
,8
,9
]}

Van Hulle, Carol ^{[10
]}

Carlsson, Cindy ^{[11
,12
,13
,14
]}

Chapman, M. John ^{[15
,16
]}

Toth, Peter P. ^{[17
,18
]}

机构：

[1] Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA

[3] Univ Leeds, Leeds Inst Med Res, Div Gastrointestinal & Surg Sci, St Jamess Univ Hosp, Leeds LS9 7TF, W Yorkshire, England

[4] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 665 Huntington Ave, Boston, MA 02115 USA

[5] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA

[6] Massachusetts Gen Hosp, Mongan Inst, Clin & Translat Epidemiol Unit, 100 Cambridge St, Boston, MA 02114 USA

[7] Harvard Med Sch, 100 Cambridge St, Boston, MA 02114 USA

[8] Massachusetts Gen Hosp, Div Gastroenterol, 50 Fruit St, Boston, MA 02114 USA

[9] Harvard Med Sch, 50 Fruit St, Boston, MA 02114 USA

[10] Univ Wisconsin, Madison Sch Med & Publ Hlth, Madison, WI USA

[11] Madison VA Geriatr Res Educ & Clin Ctr GRECC, William S Middleton Mem Vet Hosp, 2500 Overlook Terrace, Madison, WI 53705 USA

[12] Univ Wisconsin, Div Geriatr & Gerontol, Sch Med & Publ Hlth, Madison, WI USA

[13] Wisconsin Alzheimers Dis Res Ctr ADRC, 600 Highland Ave,J5-1 Mezzanine, Madison, WI 53792 USA

[14] Wisconsin Alzheimers Inst WAI, 610 Walnut St Suite 957, Madison, WI 53726 USA

[15] Sorbonne Univ, 21 Rue Ecole Med, F-75006 Paris, France

[16] Pitie Salpetriere Univ Hosp, Endocrinol Metab Div, 47-83 Blvd Hop, F-75651 Paris, France

[17] CGH Med Ctr, 101 East Miller Rd, Sterling, IL 61081 USA

[18] Johns Hopkins Univ, Cicarrone Ctr Prevent Cardiovasc Dis, Sch Med, Baltimore, MD USA

来源：

EUROPEAN HEART JOURNAL SUPPLEMENTS | 2020年 / 22卷 / 0J期

关键词：

Icosapent ethyl; Colorectal cancer; Coronavirus; Inflammation; Alzheimer's disease; Depression; POLYUNSATURATED FATTY-ACIDS; INTESTINAL ALKALINE-PHOSPHATASE; EICOSAPENTAENOIC ACID; ALZHEIMERS-DISEASE; DOUBLE-BLIND; RISK-FACTORS; DEMENTIA; DEPRESSION; OMEGA-3-FATTY-ACIDS; RESOLUTION;

D O I：

10.1093/eurheartj/suaa119

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The REDUCE-IT trial demonstrated that icosapent ethyl, an ethyl ester of eicosapen-taenoic acid (EPA), reduced cardiovascular events in an at-risk population by a substantial degree. While the cardiovascular protective properties of this compound are now proven, several other potential uses are being actively explored in clinical studies. These areas of investigation include cancer, inflammatory bowel disease, infections, Alzheimer's disease, dementia, and depression. The next decade promises to deepen our understanding of the beneficial effects that EPA may offer beyond cardiovascular risk reduction.

引用

页码：J54 / J64

页数：11

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