Surgical Management of Pancreatic Neuroendocrine Tumors

被引：34

作者：

Clancy, Thomas E. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Div Surg Oncol, Boston, MA 02115 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 01期

关键词：

Neuroendocrine; Pancreas; Pancreatectomy; Surgery; Enucleation; ZOLLINGER-ELLISON-SYNDROME; ENDOCRINE NEOPLASIA TYPE-1; LONG-TERM SURVIVAL; SOMATOSTATIN-RECEPTOR SCINTIGRAPHY; ISLET CELL TUMORS; LIVER METASTASES; HYPERINSULINEMIC HYPOGLYCEMIA; HEPATIC METASTASES; SURGERY; RESECTION;

D O I：

10.1016/j.hoc.2015.09.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic neuroendocrine tumors (PNETs) are uncommon tumors with a range of clinical behavior. Some PNETs are associated with symptoms of hormone secretion, with increased systemic levels of insulin, gastrin, glucagon, or other hormones. More commonly, PNETs are nonfunctional, without hormone secretion. Surgical resection is the mainstay of therapy, particularly for localized disease. Surgical therapy must be tailored to tumor and clinical characteristics. Resection may be particularly indicated in the setting of hormone hypersecretion. Small, incidental PNETs are increasingly managed nonoperatively. Surgery may also be indicated in some instances of metastatic disease, if all metastatic foci may be removed.

引用

页码：103 / +

页数：17

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