Exhaled nitric oxide in paediatric asthma and cystic fibrosis

被引:208
作者
Lundberg, JON
Nordvall, SL
Weitzberg, E
Kollberg, H
Alving, K
机构
[1] KAROLINSKA HOSP,DEPT ANAESTHESIOL & INTENS CARE,S-10401 STOCKHOLM,SWEDEN
[2] KAROLINSKA INST,ST GORANS CHILDRENS HOSP,S-11281 STOCKHOLM,SWEDEN
[3] UNIV HOSP,UPPSALA,SWEDEN
关键词
Kartagener's syndrome; nitric oxide synthase; chemiluminescence;
D O I
10.1136/adc.75.4.323
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Nitric oxide (NO) is present in exhaled air of humans. This NO is mostly produced in the upper airways, whereas basal NO excretion in the lower airways is low, Children with Kartagener's syndrome have an almost total lack of NO in nasally derived air, whereas adult asthmatics have increased NO in orally exhaled air. NO excretion was measured in the nasal cavity and in orally exhaled air in 19 healthy children, in 36 age matched subjects with asthma, and in eight children with cystic fibrosis. NO levels in orally exhaled air were similar in controls and in children with cystic fibrosis, at 4.8 (SD 1.2) v 5.8 (0.8) parts per billion (ppb), but were increased in asthmatic children who were untreated or were being treated only with low doses of inhaled steroids (13.8 (2.5) ppb). Nasal NO levels were reduced by about 70% in children with cystic fibrosis compared to controls and asthmatics. Measurements of airway NO release in different parts of the airways may be useful in non-invasive diagnosis and monitoring of inflammatory airway diseases.
引用
收藏
页码:323 / 326
页数:4
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