The Dimeric Proto-Ribosome: Structural Details and Possible Implications on the Origin of Life

被引：51

作者：

Agmon, Ilana ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2009年 / 10卷 / 07期

关键词：

proto-ribosome; origin of life; ribosome symmetrical region; PEPTIDE-BOND FORMATION; TRANSFER-RNA; GNRA TETRALOOP; GAAA TETRALOOP; GENETIC-CODE; EVOLUTION; TRANSLOCATION; MITOCHONDRIAL; RECOGNITION; SPECIFICITY;

D O I：

10.3390/ijms10072921

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A symmetric pocket-like entity, composed of two L-shaped RNA units, encircles the peptide synthesis site within the contemporary ribosome. This entity was suggested to be the vestige of a dimeric proto-ribosome, which could have formed spontaneously in the prebiotic world, catalyzing non-coded peptide bond formation and elongation. This structural element, beyond offering the initial step in the evolution of translation, is hypothesized here to be linked to the origin of life. By catalyzing the production of random peptide chains, the proto-ribosome could have enabled the formation of primary enzymes, launching a process of co-evolution of the translation apparatus and the proteins, thus presenting an alternative to the RNA world hypothesis.

引用

页码：2921 / 2934

页数：14

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